Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680827 | 0.88 | KMT2A (0.50) | KDM4EMEN1PRNPPOLBGAA | |
| SCHEMBL13680844 | 0.84 | SMN1; SMN2 (0.43) | KDM4EMEN1PRNPPOLBGAA | |
| SCHEMBL13680837 | 0.81 | ALDH1A1 (0.40) | TSHRKDM4EMEN1KMT2A | |
| SCHEMBL13680842 | 0.79 | RAB9A (0.45) | TSHRKDM4EGAAKMT2A | |
| SCHEMBL13680831 | 0.78 | PDE10A (0.37) | AOC3 | |
| SCHEMBL13680825 | 0.78 | MAPT (0.41) | POLBKMT2A | |
| SCHEMBL13680940 | 0.78 | TP53 (0.45) | MEN1POLBKMT2A | |
| SCHEMBL13680483 | 0.77 | TSHR (0.49) | TSHRAOC3PNPLA2HDAC6MEN1 | |
| SCHEMBL13680843 | 0.77 | HPGD (0.45) | KDM4EMEN1POLBKMT2A | |
| SCHEMBL13680836 | 0.77 | NPC1 (0.44) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |