Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680827 | 0.89 | KMT2A (0.50) | SMN1; SMN2HPGDMAPTKMT2AKDM4E | |
| SCHEMBL13680841 | 0.84 | TSHR (0.40) | KMT2AKDM4EMEN1PRNPPOLB | |
| SCHEMBL13680828 | 0.82 | ALDH1A1 (0.42) | SMN1; SMN2HPGDMAPTKMT2AKDM4E | |
| SCHEMBL13680839 | 0.80 | ALDH1A1 (0.45) | SMN1; SMN2HPGDMAPTKMT2AKDM4E | |
| SCHEMBL13680815 | 0.79 | PDE10A (0.46) | SMN1; SMN2HPGDMAPTKMT2AKDM4E | |
| SCHEMBL13680825 | 0.79 | MAPT (0.41) | SMN1; SMN2HPGDMAPTKMT2APOLB | |
| SCHEMBL13680840 | 0.79 | RAB9A (0.41) | SMN1; SMN2HPGDMAPTKMT2AMEN1 | |
| SCHEMBL13680843 | 0.78 | HPGD (0.45) | SMN1; SMN2HPGDMAPTKMT2AKDM4E | |
| SCHEMBL13680836 | 0.78 | NPC1 (0.44) | SMN1; SMN2NQO2MAPTNPC1RAB9A | |
| SCHEMBL13680834 | 0.77 | PDE10A (0.39) | SMN1; SMN2HPGDMAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |