Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680844 | 0.89 | SMN1; SMN2 (0.43) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL13680841 | 0.88 | TSHR (0.40) | KMT2AMEN1KDM4EGAAPOLB | |
| SCHEMBL13680825 | 0.82 | MAPT (0.41) | KMT2AALDH1A1MAPTHPGDPOLB | |
| SCHEMBL13680843 | 0.81 | HPGD (0.45) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL13680828 | 0.81 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL13680836 | 0.81 | NPC1 (0.44) | MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL13680834 | 0.80 | PDE10A (0.39) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL13680830 | 0.80 | RARA (0.44) | ALDH1A1KDM4EGAAPOLBSMN1; SMN2 | |
| SCHEMBL13680840 | 0.79 | RAB9A (0.41) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL13680835 | 0.78 | MAP4K4 (0.42) | RAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |