Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680834 | 0.84 | PDE10A (0.39) | PDE10AIRAK4TRPV3RAB9A | |
| SCHEMBL13680848 | 0.83 | ADK (0.40) | NPC1RAB9AKCNH2SCN9A | |
| SCHEMBL13680846 | 0.83 | MAPT (0.40) | PDE10ACYP2A6TRPV3SCN9AGRM5 | |
| SCHEMBL13680849 | 0.82 | SCN9A (0.43) | CYP2A6SCN9AGRM5 | |
| SCHEMBL13680850 | 0.80 | TRPV3 (0.53) | TRPV3KCNH2SCN9A | |
| SCHEMBL13680852 | 0.79 | CYP2A6 (0.51) | PDE10ACYP2A6IRAK4NPC1RAB9A | |
| SCHEMBL3854280 | 0.79 | MEN1 (0.50) | PDE10ATRPV3RAB9AKCNH2WNT3A | |
| SCHEMBL13680851 | 0.78 | MAPK1 (0.43) | PDE10AGRM5 | |
| SCHEMBL13680815 | 0.77 | PDE10A (0.46) | PDE10ANPC1RAB9AHRH3SCN9A | |
| SCHEMBL13680831 | 0.77 | PDE10A (0.37) | PDE10ACYP2A6TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |