Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 7/20 | 0.38 |
| ▸ | RHOC | P08134 | 1/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680953 | 0.83 | LMNA (0.41) | LMNAKDM4ESMN1; SMN2POLBMAPT | |
| SCHEMBL13680956 | 0.82 | SHMT2 (0.40) | LMNAKDM4ESMN1; SMN2POLBMAPT | |
| SCHEMBL13680930 | 0.82 | LMNA (0.55) | LMNAKDM4ESMN1; SMN2POLBHTT | |
| SCHEMBL13680955 | 0.81 | GAA (0.42) | CPT1ALMNAKDM4ESMN1; SMN2POLB | |
| SCHEMBL13680954 | 0.79 | KDM4E (0.40) | LMNAKDM4ESMN1; SMN2POLBMAPT | |
| SCHEMBL18002719 | 0.78 | MAPT (0.50) | CPT1AMAPT | |
| SCHEMBL13680959 | 0.78 | CYP19A1 (0.53) | CPT1ALMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13681331 | 0.78 | CHEK1 (0.41) | LMNAKDM4ESMN1; SMN2POLBMAPT | |
| SCHEMBL13680949 | 0.78 | HPGDS (0.43) | LMNAKDM4ESMN1; SMN2MAPTTP53 | |
| SCHEMBL13680850 | 0.77 | TRPV3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |