SCHEMBL1369210

SCHEMBL1369210

c1csc(Nc2nccs2)n1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
TDP1 Q9NUW8 3/20 0.50
ACP1 P24666 2/20 0.48
FDPS P14324 1/20 0.47
PLA2G7 Q13093 1/20 0.46
GRM4 Q14833 1/20 0.46
LMNA P02545 4/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
CYP2C9 P11712 2/20 0.46
HSD17B10 Q99714 2/20 0.46
KDM4E B2RXH2 1/20 0.46
EDNRA P25101 1/20 0.46
SLC6A4 P31645 1/20 0.46
ADRA1A P35348 1/20 0.46
PRMT6 Q96LA8 1/20 0.46
TSHR P16473 1/20 0.46
NOS1 P29475 1/20 0.46
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
NPC1 O15118 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyridine SCHEMBL28371825 0.86 ALDH1A1 (0.46) ALDH1A1TDP1ACP1PLA2G7GRM4
SCHEMBL2546678 0.83 GRM4 (0.47) ALDH1A1TDP1ACP1FDPSPLA2G7
SCHEMBL14048344 0.79 ALDH1A1 (0.45) ALDH1A1TDP1ACP1FDPSPLA2G7
SCHEMBL8629253 0.79 ALDH1A1 (0.38) ALDH1A1TDP1ACP1FDPSPLA2G7
SCHEMBL722560 0.79 RAB9A (0.59) ALDH1A1TDP1PLA2G7LMNASMN1; SMN2
SCHEMBL17397927 0.79 PLA2G7 (0.49) ALDH1A1TDP1PLA2G7GRM4LMNA
SCHEMBL14281292 0.78
SCHEMBL2807100 0.78
SCHEMBL13879142 0.78
SCHEMBL454310 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7858724-B2 Polymeric, phosphorescent, organically semi-conductive emitter materials based on perarylated boranes, method for their production and use thereof OSRAM OPTO SEMICONDUCTORS GMBH (DE) 2010-12-28 US claimed
EP-1699898-B1 POLYMERIC, PHOSPHORESCENT, ORGANICALLY SEMI-CONDUCTIVE EMITTER MATERIALS BASED ON PERARYLATED BORANES, METHOD FOR THEIR PRODUCTION AND USE THEREOF OSRAM OPTO SEMICONDUCTORS GMBH (DE) 2008-10-29 EP claimed
US-20070191587-A1 Polymeric, phosphorescent, organically semi-conductive emitter materials based on perarylated boranes, method for their production and use thereof OSRAM OLED GMBH (DE) 2007-08-16 US claimed
CN-113200939-A Bis (1, 3-thiazole) amine and preparation method thereof 广东石油化工学院 2021-08-03 CN disclosed
CN-113200939-A Bis (1, 3-thiazole) amine and preparation method thereof 广东石油化工学院 2021-08-03 CN disclosed
US-20110288136-A1 FLAVIVIRUS INHIBITION BY SULTAMS AND RELATED COMPOUNDS OREGON HEALTH & SCIENCE UNIVERSITY 2011-11-24 US disclosed
US-8003674-B2 Flavivirus inhibition by sultams and related compounds OREGON HEALTH & SCIENCE UNIVERSITY (US) 2011-08-23 US disclosed
US-7858724-B2 Polymeric, phosphorescent, organically semi-conductive emitter materials based on perarylated boranes, method for their production and use thereof OSRAM OPTO SEMICONDUCTORS GMBH (DE) 2010-12-28 US disclosed
US-20100234434-A1 FLAVIVIRUS INHIBITION BY SULTAMS AND RELATED COMPOUNDS OREGON HEALTH & SCIENCE UNIVERSITY 2010-09-16 US disclosed
EP-1994491-A2 FLAVIVIRUS INHIBITION BY SULTAMS AND RELATED COMPOUNDS Oregon Health and Science University (US) 2008-11-26 EP disclosed
WO-2007109105-A2 FLAVIVIRUS INHIBITION BY SULTAMS AND RELATED COMPOUNDS OREGON HEALTH & SCIENCE UNIVERSITY (US) 2007-09-27 WO disclosed
US-20070191587-A1 Polymeric, phosphorescent, organically semi-conductive emitter materials based on perarylated boranes, method for their production and use thereof OSRAM OLED GMBH (DE) 2007-08-16 US disclosed
US-20070184232-A1 Optical recording materials having high storage density CIBA SPECIALTY CHEMICALS CORP. 2007-08-09 US disclosed
EP-1719126-A1 OPTICAL RECORDING MATERIALS HAVING HIGH STORAGE DENSITY CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) 2006-11-08 EP disclosed
WO-2005081239-A1 OPTICAL RECORDING MATERIALS HAVING HIGH STORAGE DENSITY CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2005-09-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110288136-A1 FLAVIVIRUS INHIBITION BY SULTAMS AND RELATED COMPOUNDS SHMT1, SULT2A1, GNMT ALDH1A1 1585/4885TDP1 2703/4885ACP1 4045/4885
US-20100234434-A1 FLAVIVIRUS INHIBITION BY SULTAMS AND RELATED COMPOUNDS SHMT1, SULT2A1, GNMT ALDH1A1 1585/4885TDP1 2703/4885ACP1 4045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.