SCHEMBL137568

SCHEMBL137568

CC(C)CNC(=O)N(C)C

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.54
CYP2C19 P33261 1/20 0.54
CHRNB2 P17787 1/20 0.52
CHRNB4 P30926 1/20 0.52
CHRNA4 P43681 1/20 0.52
MMP1 P03956 1/20 0.46
MMP8 P22894 1/20 0.46
KMT2A Q03164 3/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
EPHX1 P07099 2/20 0.39
MAPT P10636 2/20 0.39
HSD17B10 Q99714 2/20 0.39
GAA P10253 1/20 0.39
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
TAS1R2 Q8TE23 1/20 0.38
ALDH1A1 P00352 3/20 0.38
ACACB O00763 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2195619 0.83 CHRNB2 (0.50) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA4
SCHEMBL11634044 0.81 CYP2D6 (0.50) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA4
SCHEMBL12764421 0.81 CYP2C19 (0.50) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA4
SCHEMBL14011282 0.79 CYP2D6 (0.48) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA4
SCHEMBL10770658 0.78 CHRNB2 (0.46) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA4
SCHEMBL4301028 0.76 CYP2D6 (0.50) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA4
SCHEMBL14617684 0.76 CHRNB2 (0.70) CYP2C19CHRNB2CHRNB4CHRNA4MMP8
SCHEMBL27750762 0.76 CYP2D6 (0.50) CYP2D6CYP2C19MMP1MMP8KMT2A
SCHEMBL11632183 0.75 CYP2D6 (0.48) CYP2D6CYP2C19MMP1MMP8KMT2A
SCHEMBL23204284 0.74 CYP2D6 (0.43) CYP2D6CYP2C19CHRNB2CHRNB4CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3472220-B1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM SIKA TECH AG (CH) 2022-12-21 EP claimed
US-11161950-B2 Article of thermosetting epoxy resin composition and carbon fibre fabric, and reinforced structural component made therewith SIKA TECHNOLOGY AG (CH) 2021-11-02 US claimed
US-10767040-B2 Thermosetting epoxy resin compositions useful as structural reinforcement or structural foam SIKA TECHNOLOGY AG (CH) 2020-09-08 US claimed
EP-3339356-B1 AN ARTICLE OF THERMOSETTING EPOXY RESIN COMPOSITION AND CARBON FIBRE FABRIC, AND REINFORCED STRUCTURAL COMPONENT MADE THEREWITH SIKA TECH AG (CH) 2019-10-30 EP claimed
US-20190270879-A1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2019-09-05 US claimed
EP-3472220-A1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM Sika Technology AG (CH) 2019-04-24 EP claimed
EP-3339356-A1 AN ARTICLE OF THERMOSETTING EPOXY RESIN COMPOSITION AND CARBON FIBRE FABRIC, AND REINFORCED STRUCTURAL COMPONENT MADE THEREWITH SIKA TECHNOLOGY AG (CH) 2018-06-27 EP claimed
US-20180171087-A1 ARTICLE OF THERMOSETTING EPOXY RESIN COMPOSITION AND CARBON FIBRE FABRIC, AND REINFORCED STRUCTURAL COMPONENT MADE THEREWITH SIKA TECHNOLOGY AG (CH) 2018-06-21 US claimed
WO-2017220583-A1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2017-12-28 WO claimed
US-9475904-B2 Heat curable epoxy resin composition with water as foaming agent SIKA TECHNOLOGY AG (CH) 2016-10-25 US claimed
US-9187592-B2 Hot-curing epoxy resin compositions that can be used as bodyshell adhesive or structural foam SIKA TECHNOLOGY AG (CH) 2015-11-17 US claimed
US-20150275059-A1 HOT-CURING EPOXY RESIN COMPOSITIONS THAT CAN BE USED AS BODYSHELL ADHESIVE OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2015-10-01 US claimed
EP-2655535-B1 HET-CURING SEALANT COMPOSITION WITH FAST SKINNING AND HIGH TENSILE STRENGTH SIKA TECHNOLOGY AG (CH) 2015-04-15 EP claimed
EP-2426160-B1 Heat curable epoxy resin composition with water as foaming agent SIKA TECHNOLOGY AG (CH) 2014-01-15 EP claimed
US-20130280536-A1 HEAT-CURING SEALANT COMPOSITIONS HAVING FAST SKIN FORMATION AND HIGH TENSILE STRENGTH SIKA TECHNOLOGY AG (CH) 2013-10-24 US claimed
US-20120055631-A1 HEAT CURABLE EPOXY RESIN COMPOSITION WITH WATER AS FOAMING AGENT SIKA TECHNOLOGY AG (CH) 2012-03-08 US claimed
EP-2182025-B1 Heat curable epoxide resin compositions suitable as bodyshop adhesive or structural foam SIKA TECHNOLOGY AG (CH) 2010-10-06 EP claimed
EP-2161274-B1 Silane/urea compound as heat-activated hardener for epoxy resin compounds SIKA TECHNOLOGY AG (CH) 2010-05-19 EP claimed
US-20100108258-A1 HOT-CURING EPOXY RESIN COMPOSITIONS THAT CAN BE USED AS BODYSHELL ADHESIVE OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2010-05-06 US claimed
EP-4724521-A1 THERMALLY EXPANDABLE COMPOSITIONS WITH REDUCED ODOR EMISSION Sika Technology AG (CH) 2026-04-15 EP disclosed
EP-4127016-B1 ONE-COMPONENT THERMOSETTING EPOXY COMPOSITION WITH IMPROVED ADHESION SIKA TECH AG (CH) 2025-05-07 EP disclosed
WO-2024251917-A1 THERMALLY EXPANDABLE COMPOSITIONS WITH REDUCED ODOR EMISSION SIKA TECHNOLOGY AG (CH) 2024-12-12 WO disclosed
WO-2024059665-A1 DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF MAZE THERAPEUTICS, INC. (US) 2024-03-21 WO disclosed
US-20240072809-A1 ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS AVILAR THERAPEUTICS, INC. (US) 2024-02-29 US disclosed
EP-4282908-A1 ONE-COMPONENT THERMOSETTING EPOXY COMPOSITION WITH IMPROVED ADHESION Sika Technology AG (CH) 2023-11-29 EP disclosed
US-11819551-B2 ASGPR-binding compounds for the degradation of extracellular proteins AVILAR THERAPEUTICS, INC. (US) 2023-11-21 US disclosed
US-11814367-B2 Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof MAZE THERAPEUTICS, INC. (US) 2023-11-14 US disclosed
US-11814367-B2 Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof MAZE THERAPEUTICS, INC. (US) 2023-11-14 US disclosed
US-20230233689-A1 Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins UNIV YALE (US) 2023-07-27 US disclosed
US-20230097570-A1 ONE-COMPONENT THERMOSETTING EPOXY COMPOSITION WITH IMPROVED ADHESION SIKA TECHNOLOGY AG (CH) 2023-03-30 US disclosed
EP-4127016-A1 ONE-COMPONENT THERMOSETTING EPOXY COMPOSITION WITH IMPROVED ADHESION Sika Technology AG (CH) 2023-02-08 EP disclosed
EP-3472220-B1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM SIKA TECH AG (CH) 2022-12-21 EP disclosed
WO-2022198196-A1 INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF MAZE THERAPEUTICS, INC. (US) 2022-09-22 WO disclosed
WO-2022188729-A1 FUSED RING DERIVATIVES USEFUL AS KRAS G12D INHIBITORS JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2022-09-15 WO disclosed
US-11161950-B2 Article of thermosetting epoxy resin composition and carbon fibre fabric, and reinforced structural component made therewith SIKA TECHNOLOGY AG (CH) 2021-11-02 US disclosed
WO-2021190970-A1 ONE-COMPONENT THERMOSETTING EPOXY COMPOSITION WITH IMPROVED ADHESION SIKA TECHNOLOGY AG (CH) 2021-09-30 WO disclosed
EP-3885389-A1 ONE-COMPONENT THERMOSETTING EPOXY COMPOSITION WITH IMPROVED ADHESION SIKA TECHNOLOGY AG (CH) 2021-09-29 EP disclosed
US-10767040-B2 Thermosetting epoxy resin compositions useful as structural reinforcement or structural foam SIKA TECHNOLOGY AG (CH) 2020-09-08 US disclosed
EP-3185347-B1 NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY MITSUBISHI CHEM CORP (JP) 2020-05-13 EP disclosed
WO-2020072391-A1 SMALL MOLECULE MENIN INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2020-04-09 WO disclosed
EP-3339356-B1 AN ARTICLE OF THERMOSETTING EPOXY RESIN COMPOSITION AND CARBON FIBRE FABRIC, AND REINFORCED STRUCTURAL COMPONENT MADE THEREWITH SIKA TECH AG (CH) 2019-10-30 EP disclosed
US-20190270879-A1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2019-09-05 US disclosed
EP-2809652-B1 ISOQUINOLINE AND NAPHTHYRIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2019-05-15 EP disclosed
EP-3472220-A1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM Sika Technology AG (CH) 2019-04-24 EP disclosed
EP-3049478-B1 A CURABLE EPOXY RESIN COMPOSITION BLUE CUBE IP LLC (US) 2018-08-01 EP disclosed
EP-3339356-A1 AN ARTICLE OF THERMOSETTING EPOXY RESIN COMPOSITION AND CARBON FIBRE FABRIC, AND REINFORCED STRUCTURAL COMPONENT MADE THEREWITH SIKA TECHNOLOGY AG (CH) 2018-06-27 EP disclosed
US-20180171087-A1 ARTICLE OF THERMOSETTING EPOXY RESIN COMPOSITION AND CARBON FIBRE FABRIC, AND REINFORCED STRUCTURAL COMPONENT MADE THEREWITH SIKA TECHNOLOGY AG (CH) 2018-06-21 US disclosed
US-9915037-B2 Simple application of an adhesive material to a substrate with excellent adhesion to asphalt SIKA TECHNOLOGY AG (CH) 2018-03-13 US disclosed
WO-2017220583-A1 THERMOSETTING EPOXY RESIN COMPOSITIONS USEFUL AS STRUCTURAL REINFORCEMENT OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2017-12-28 WO disclosed
US-9512341-B2 Heat-curing sealant compositions having fast skin formation and high tensile strength SIKA TECHNOLOGY AG (CH) 2016-12-06 US disclosed
US-20160340837-A1 APPLICATION OF A RANDOM-LAID WEB FOR ROADWAY CONSTRUCTION WITH IMPROVED ADHESION PROPERTIES SIKA TECHNOLOGY AG (CH) 2016-11-24 US disclosed
US-20160340839-A1 SIMPLE APPLICATION OF AN ADHESIVE MATERIAL TO A SUBSTRATE WITH EXCELLENT ADHESION TO ASPHALT SIKA TECHNOLOGY AG (CH) 2016-11-24 US disclosed
US-9475904-B2 Heat curable epoxy resin composition with water as foaming agent SIKA TECHNOLOGY AG (CH) 2016-10-25 US disclosed
US-20160257811-A1 A CURABLE EPOXY RESIN COMPOSITION DOW CHEMICAL (CHINA) INVESTMENT COMPANY LIMITED (CN) 2016-09-08 US disclosed
EP-3049478-A1 A CURABLE EPOXY RESIN COMPOSITION Blue Cube IP LLC (US) 2016-08-03 EP disclosed
US-9284447-B2 Silane/urea compound as a heat-activated curing agent for epoxide resin compositions SIKA TECHNOLOGY AG (CH) 2016-03-15 US disclosed
US-9187592-B2 Hot-curing epoxy resin compositions that can be used as bodyshell adhesive or structural foam SIKA TECHNOLOGY AG (CH) 2015-11-17 US disclosed
US-20150275059-A1 HOT-CURING EPOXY RESIN COMPOSITIONS THAT CAN BE USED AS BODYSHELL ADHESIVE OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2015-10-01 US disclosed
US-20150252165-A1 EXPANDABLE COMPOSITION IN THE FORM OF A GRANULAR MATERIAL SIKA TECHNOLOGY AG (CH) 2015-09-10 US disclosed
WO-2015042823-A1 A CURABLE EPOXY RESIN COMPOSITION DOW GLOBAL TECHNOLOGIES LLC (US) 2015-04-02 WO disclosed
US-20140216655-A1 SILANE/UREA COMPOUND AS A HEAT-ACTIVATED CURING AGENT FOR EPOXIDE RESIN COMPOSITIONS SIKA TECHNOLOGY AG (CH) 2014-08-07 US disclosed
US-8728271-B2 Silane/urea compound as a heat-activatable curing agent for epoxide resin compositions SIKA TECHNOLOGY AG (CH) 2014-05-20 US disclosed
US-20130280526-A1 HEAT-CURING SEALING COMPOUND COMPOSITIONS HAVING FAST SKIN FORMATION AND GOOD STORAGE STABILITY SIKA TECHNOLOGY AG (CH) 2013-10-24 US disclosed
US-20130280536-A1 HEAT-CURING SEALANT COMPOSITIONS HAVING FAST SKIN FORMATION AND HIGH TENSILE STRENGTH SIKA TECHNOLOGY AG (CH) 2013-10-24 US disclosed
US-8534953-B2 Roadway structure having improved adhesive properties SIKA TECHNOLOGY AG (CH) 2013-09-17 US disclosed
US-20130157048-A1 SEALING MEMBRANE WITH IMPROVED ADHESION SIKA TECHNOLOGY AG (CH) 2013-06-20 US disclosed
US-20130060013-A1 Compounds useful for treating neurodegenerative disorders SATORI PHARMACEUTICALS, INC. (US) 2013-03-07 US disclosed
US-20120170977-A1 ROADWAY STRUCTURE HAVING IMPROVED ADHESIVE PROPERTIES SIKA TECHNOLOGY AG (CH) 2012-07-05 US disclosed
US-20120055631-A1 HEAT CURABLE EPOXY RESIN COMPOSITION WITH WATER AS FOAMING AGENT SIKA TECHNOLOGY AG (CH) 2012-03-08 US disclosed
US-20110155320-A1 SILANE/UREA COMPOUND AS A HEAT-ACTIVATABLE CURING AGENT FOR EPOXIDE RESIN COMPOSITIONS SIKA TECHNOLOGY AG (CH) 2011-06-30 US disclosed
US-20110130479-A1 ADHESION PROMOTER COMPOUNDS FOR OILED STEEL SIKA TECHNOLOGY AG (CH) 2011-06-02 US disclosed
US-20110114257-A1 REACTION PRODUCTS BASED ON AMPHIPHILIC BLOCK COPOLYMERS AND THEIR USE AS IMPACT MODIFIER SIKA TECHNOLOGY AG (CH) 2011-05-19 US disclosed
US-7897622-B2 2-amido-5-oxo/thio-benzoic acid derivatives; hepatitis C virus infection; synergistic with another inhibitor of HCV polymerase or immunomodulatory agent such as interferons BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-01 US disclosed
US-7897622-B2 2-amido-5-oxo/thio-benzoic acid derivatives; hepatitis C virus infection; synergistic with another inhibitor of HCV polymerase or immunomodulatory agent such as interferons BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-01 US disclosed
US-20100108258-A1 HOT-CURING EPOXY RESIN COMPOSITIONS THAT CAN BE USED AS BODYSHELL ADHESIVE OR STRUCTURAL FOAM SIKA TECHNOLOGY AG (CH) 2010-05-06 US disclosed
US-20080045516-A1 Viral Polymerase Inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-02-21 US disclosed
US-20080045516-A1 Viral Polymerase Inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-02-21 US disclosed
US-20080045516-A1 Viral Polymerase Inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11819551-B2 ASGPR-binding compounds for the degradation of extracellular proteins ASGR1, ENGASE, FCGR2A CYP2D6 4501/4885CYP2C19 4615/4885CHRNB2 2758/4885
US-11814367-B2 Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof GYS2, GYS1, PYGL CYP2D6 1746/4885CYP2C19 3075/4885CHRNB2 1168/4885
US-20110130479-A1 ADHESION PROMOTER COMPOUNDS FOR OILED STEEL ELL, MED1, HSF1 CYP2D6 3912/4885CYP2C19 2314/4885CHRNB2 3129/4885
US-20230233689-A1 Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins ASGR1, LDLR, FCGR2A CYP2D6 2423/4885CYP2C19 2385/4885CHRNB2 1673/4885
US-20130060013-A1 Compounds useful for treating neurodegenerative disorders SNCA, HTT, CLN6 CYP2D6 3452/4885CYP2C19 3852/4885CHRNB2 122/4885
US-20110155320-A1 SILANE/UREA COMPOUND AS A HEAT-ACTIVATABLE CURING AGENT FOR EPOXIDE RESIN COMPOSITIONS SEM1, UBA1, UBA3 CYP2D6 2840/4885CYP2C19 1458/4885CHRNB2 4492/4885
US-20080045516-A1 Viral Polymerase Inhibitors POLR2A, POLR2H, POLR2E CYP2D6 465/4885CYP2C19 712/4885CHRNB2 4762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.