SCHEMBL1383227

SCHEMBL1383227

CC(CNC(=O)c1cnc(NCc2cccs2)nc1-c1ccccc1)C(O)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
HPGD P15428 4/20 0.42
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
FLT3 P36888 1/20 0.42
TYRO3 Q06418 1/20 0.42
MERTK Q12866 1/20 0.42
GAS6 Q14393 1/20 0.42
LMNA P02545 5/20 0.41
MAPK1 P28482 1/20 0.41
TSHR P16473 2/20 0.41
HSD17B10 Q99714 2/20 0.41
USP2 O75604 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
HIF1A Q16665 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1383520 0.87 THRB (0.52) HDAC3HDAC1HDAC2HDAC6FLT3
SCHEMBL1383650 0.84 LMNA (0.43) ALDH1A1HDAC3HDAC1HDAC2HDAC6
SCHEMBL3442903 0.79 KDM4C (0.53) ALDH1A1HPGDHDAC3HDAC1HDAC2
SCHEMBL3946248 0.76 NPY5R (0.42) ALDH1A1HPGDHDAC3HDAC1HDAC2
SCHEMBL3443587 0.75 ALDH1A1 (0.58) ALDH1A1HPGDHDAC3HDAC1HDAC2
SCHEMBL1384191 0.74 CASR (0.55) ALDH1A1LMNATHRBCASRMAPT
SCHEMBL1384100 0.73 FYN (0.39) ALDH1A1HPGDHDAC3HDAC1HDAC2
SCHEMBL3945243 0.67 FYN (0.39) ALDH1A1HPGDHDAC3HDAC1HDAC2
SCHEMBL1384551 0.64 CASR (0.46) CASRRAB9ANPC1KMT2A
SCHEMBL3442955 0.63 ATM (0.57) HDAC3HDAC1HDAC2HDAC6THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4825686-B2 2011-11-30 JP claimed