Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | GPR39 | O43194 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16155933 | 0.88 | RAB9A (0.51) | CHRNA7NPC1RAB9AP2RX7GPR39 | |
| SCHEMBL13720752 | 0.81 | CHRNA7 (0.37) | CHRNA7CCR5ALDH1A1KMT2ALMNA | |
| SCHEMBL13858557 | 0.77 | HPGD (0.44) | NPC1RAB9AP2RX7ALDH1A1KMT2A | |
| SCHEMBL16156008 | 0.77 | OGFRL1 (0.42) | ALDH1A1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL16156007 | 0.77 | OGFRL1 (0.42) | ALDH1A1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL13858643 | 0.75 | LMNA (0.54) | RAB9AALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL16155973 | 0.75 | LMNA (0.57) | KMT2ALMNASMN1; SMN2POLBUSP2 | |
| SCHEMBL13858646 | 0.73 | ALDH1A1 (0.50) | NPC1RAB9AALDH1A1KMT2ALMNA | |
| SCHEMBL25236489 | 0.72 | TEAD1 (0.52) | CHRNA7P2RX7 | |
| SCHEMBL1791098 | 0.71 | ALDH1A1 (0.45) | NPC1RAB9AP2RX7GPR39ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | claimed |
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | claimed |
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | disclosed |