Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787363 | 0.75 | TSHR (0.61) | TSHRCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL13720543 | 0.73 | SMN1; SMN2 (0.74) | CYP1A2CYP2C9CYP2C19POLBALDH1A1 | |
| SCHEMBL13721614 | 0.71 | ALOX15 (0.42) | TSHRCYP1A2CYP2C9CYP2C19ALOX15 | |
| SCHEMBL16155933 | 0.71 | RAB9A (0.51) | TSHRPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13858643 | 0.71 | LMNA (0.54) | TSHRCYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL13858810 | 0.70 | KDM4E (0.66) | POLBALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL13720704 | 0.69 | MEN1 (0.50) | TSHRPOLBMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1786624 | 0.69 | NPSR1 (0.56) | TSHRALDH1A1PKMSMN1; SMN2LMNA | |
| SCHEMBL1790852 | 0.68 | ADRA1A (0.60) | TSHRCYP2D6SMN1; SMN2LMNA | |
| SCHEMBL13721009 | 0.67 | ELANE (0.56) | ALOX15POLBALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | disclosed |