Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12306280 | 0.73 | HDAC8 (0.46) | ALDH1A1TSHRBCHEACHEMAPK1 | |
| SCHEMBL8276398 | 0.71 | BCHE (0.31) | ALDH1A1TSHRTDP1BCHEACHE | |
| SCHEMBL28491364 | 0.70 | BCHE (0.31) | BCHEACHEMAPK1 | |
| SCHEMBL2956313 | 0.69 | — | — | |
| SCHEMBL14984825 | 0.68 | — | — | |
| SCHEMBL13876369 | 0.65 | KIF11 (0.31) | — | |
| SCHEMBL30630362 | 0.64 | LMNA (0.40) | ALDH1A1TSHRTDP1HDAC8 | |
| SCHEMBL19115525 | 0.64 | HDAC8 (0.31) | HDAC8 | |
| SCHEMBL13876365 | 0.64 | KDM4E (0.30) | ALDH1A1 | |
| SCHEMBL6640541 | 0.64 | LMNA (0.40) | ALDH1A1TSHRTDP1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230150985-A1 | INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-18 | — | — | US | disclosed |
| US-20210380575-A1 | COMPOUNDS | SYGNATURE DISCOVERY LIMITED (GB) | 2021-12-09 | — | — | US | disclosed |
| US-10696617-B2 | Method for alcoholysis of amide | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2020-06-30 | — | — | US | disclosed |
| US-20200055807-A1 | METHOD FOR ALCOHOLYSIS OF AMIDE | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2020-02-20 | — | — | US | disclosed |
| US-20170088519-A1 | AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS | BIONOMICS, LTD (AU) | 2017-03-30 | — | — | US | disclosed |
| US-9493451-B2 | Amine derivatives as potassium channel blockers | BIONOMICS LIMITED (AU) | 2016-11-15 | — | — | US | disclosed |
| US-20150299184-A1 | Amine Derivatives as Potassium Channel Blockers | BIONOMICS LIMITED (AU) | 2015-10-22 | — | — | US | disclosed |
| US-20140336198-A1 | Amine Derivatives as Potassium Channel Blockers | MERCK PATENT GMBH (DE) | 2014-11-13 | — | — | US | disclosed |
| US-20090111854-A1 | 1,2,4-TRIAZOLE ARYL N-OXIDES DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088519-A1 | AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS | KCNA3, KCNH3, KCNK3 | ALDH1A1 3267/4885TSHR 3142/4885TDP1 1900/4885 |
| US-20090111854-A1 | 1,2,4-TRIAZOLE ARYL N-OXIDES DERIVATIVES AS MODULATORS OF MGLUR5 | GRM5, GRIK5, GRM1 | ALDH1A1 3659/4885TSHR 962/4885TDP1 3556/4885 |
| US-20200055807-A1 | METHOD FOR ALCOHOLYSIS OF AMIDE | ADH1A, ADH5, ADH1C | ALDH1A1 43/4885TSHR 2649/4885TDP1 2146/4885 |
| US-20230150985-A1 | INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR | HLA-DRB1, CD74, HLA-C | ALDH1A1 1444/4885TSHR 4709/4885TDP1 3116/4885 |
| US-20210380575-A1 | COMPOUNDS | UGT1A1, CYP1A1, CYP1B1 | ALDH1A1 158/4885TSHR 4128/4885TDP1 3578/4885 |
| US-10696617-B2 | Method for alcoholysis of amide | ADH5, ADH1A, ADH1C | ALDH1A1 91/4885TSHR 2356/4885TDP1 2707/4885 |
| US-20140336198-A1 | Amine Derivatives as Potassium Channel Blockers | KCNA3, KCNH3, KCNK3 | ALDH1A1 3267/4885TSHR 3142/4885TDP1 1900/4885 |
| US-20150299184-A1 | Amine Derivatives as Potassium Channel Blockers | KCNA3, KCNH3, KCNK3 | ALDH1A1 3267/4885TSHR 3142/4885TDP1 1900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.