Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MYOC | Q99972 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CES1 | P23141 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521071 | 0.85 | TSHR (0.53) | KMT2AMEN1NPC1MAPTMAPK1 | |
| SCHEMBL27894878 | 0.84 | MAPT (0.55) | KMT2AMEN1NPC1MAPTMAPK1 | |
| SCHEMBL11203010 | 0.82 | NPC1 (0.60) | KMT2AMEN1NPC1MAPTRAB9A | |
| SCHEMBL11530611 | 0.80 | MAPT (0.51) | KMT2AMEN1MAPTMAPK1RAB9A | |
| SCHEMBL15878977 | 0.79 | KMT2A (0.58) | KMT2AMEN1MAPTRAB9APKM | |
| SCHEMBL21132495 | 0.78 | HSPB1 (0.53) | KMT2AMEN1NPC1MAPTMAPK1 | |
| SCHEMBL10014142 | 0.77 | MAPT (0.46) | KMT2AMEN1NPC1MAPTMAPK1 | |
| SCHEMBL3703542 | 0.77 | BCL9 (0.61) | KMT2AMEN1NPC1MAPTMAPK1 | |
| SCHEMBL15058988 | 0.76 | TDP1 (0.58) | KMT2AMEN1NPC1MAPK1RAB9A | |
| SCHEMBL6893926 | 0.75 | GAA (0.54) | KMT2AMEN1NPC1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154997-B9 | AURISTATIN DERIVATIVES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2021-04-14 | — | — | EP | disclosed |
| EP-3154997-B1 | AURISTATIN DERIVATIVES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2020-02-19 | — | — | EP | disclosed |
| US-10280139-B2 | Cytotoxic peptides and conjugates thereof | NOVARTIS AG (CH) | 2019-05-07 | — | — | US | disclosed |
| US-20180155281-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2018-06-07 | — | — | US | disclosed |
| US-9884817-B2 | Auristatin derivatives and conjugates thereof | NOVARTIS AG (CH) | 2018-02-06 | — | — | US | disclosed |
| US-20170121282-A1 | AURISTATIN DERIVATIVES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2017-05-04 | — | — | US | disclosed |
| EP-3154997-A1 | AURISTATIN DERIVATIVES AND CONJUGATES THEREOF | Novartis AG (CH) | 2017-04-19 | — | — | EP | disclosed |
| CN-106573956-A | Auristatin derivatives and conjugates thereof | 诺华股份有限公司 | 2017-04-19 | — | — | CN | disclosed |
| US-9448173-B2 | Dye-conjugated dendrimers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-09-20 | — | — | US | disclosed |
| WO-2015189791-A1 | AURISTATIN DERIVATIVES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2015-12-17 | — | — | WO | disclosed |
| US-20140018318-A1 | N1- and N2-CARBAMOYL-1,2,3-TRIAZOLE SERINE HYDROLASE INHIBITORS AND METHODS | THE SCIPPS RESEARCH INSTITUTE (US) | 2014-01-16 | — | — | US | disclosed |
| US-20120256102-A1 | Dye-conjugated dendrimers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2012-10-11 | — | — | US | disclosed |
| US-20120225847-A1 | SQUARIC ACID DERIVATIVES AS INHIBITORS OF THE NICOTINAMIDE | ONXEO DK, BRANCH OF ONXEO S.A., FRANCE (DK) | 2012-09-06 | — | — | US | disclosed |
| US-20120010172-A1 | NOVEL UREA AND THIOUREA DERIVATIVES | MCDERMOTT WILL & EMERY LLP (DC) | 2012-01-12 | — | — | US | disclosed |
| CN-102186822-A | Novel urea and thiourea derivatives | TOPOTARGET AS (DK) | 2011-09-14 | — | — | CN | disclosed |
| EP-2342181-A1 | NOVEL UREA AND THIOUREA DERIVATIVES | Topo Target A/S (DK) | 2011-07-13 | — | — | EP | disclosed |
| US-20110112131-A1 | Opioid-Ketamine and Norketamine Codrug Combinations for Pain Management | University of Kentucky Research Foundation A144 ASTeCC Building (US) | 2011-05-12 | — | — | US | disclosed |
| EP-2318369-A1 | SQUARIC ACID DERIVATIVES AS INHIBITORS OF THE NICOTINAMIDE | TopoTarget A/S (DK) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010023307-A1 | NOVEL UREA AND THIOUREA DERIVATIVES | TOPOTARGET A/S (DK) | 2010-03-04 | — | — | WO | disclosed |
| WO-2009156421-A1 | SQUARIC ACID DERIVATIVES AS INHIBITORS OF THE NICOTINAMIDE | TOPOTARGET A/S (DK) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018318-A1 | N1- and N2-CARBAMOYL-1,2,3-TRIAZOLE SERINE HYDROLASE INHIBITORS AND METHODS | PRSS1, PRSS3, CES1 | KMT2A 2243/4885MEN1 718/4885NPC1 748/4885 |
| US-20110112131-A1 | Opioid-Ketamine and Norketamine Codrug Combinations for Pain Management | OPRK1, OPRM1, OPRL1 | KMT2A 370/4885MEN1 4847/4885NPC1 3218/4885 |
| US-20120010172-A1 | NOVEL UREA AND THIOUREA DERIVATIVES | TST, NAMPT, NNMT | KMT2A 3380/4885MEN1 1936/4885NPC1 1720/4885 |
| US-20170121282-A1 | AURISTATIN DERIVATIVES AND CONJUGATES THEREOF | AURKC, AURKA, AURKB | KMT2A 3167/4885MEN1 986/4885NPC1 1895/4885 |
| US-20180155281-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | CD47, MKI67, NGLY1 | KMT2A 4406/4885MEN1 687/4885NPC1 700/4885 |
| US-20120225847-A1 | SQUARIC ACID DERIVATIVES AS INHIBITORS OF THE NICOTINAMIDE | SUCNR1, NAMPT, NAPRT | KMT2A 3578/4885MEN1 1915/4885NPC1 1042/4885 |
| US-10280139-B2 | Cytotoxic peptides and conjugates thereof | CD47, MKI67, NGLY1 | KMT2A 4406/4885MEN1 687/4885NPC1 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.