Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159478 | 0.82 | SLC18A3 (0.47) | SIGMAR1SLC18A3DRD2 | |
| SCHEMBL12319791 | 0.75 | DRD2 (0.60) | SIGMAR1SLC18A3DRD2MMP3MEN1 | |
| SCHEMBL6159481 | 0.75 | OPRL1 (0.44) | — | |
| SCHEMBL9070278 | 0.74 | MEN1 (0.67) | SIGMAR1DRD2MEN1KMT2A | |
| SCHEMBL3397550 | 0.73 | DRD2 (0.81) | SIGMAR1SLC18A3DRD2CARM1PRMT6 | |
| SCHEMBL8220653 | 0.72 | SLC18A3 (0.43) | SIGMAR1SLC18A3DRD2 | |
| SCHEMBL7723133 | 0.72 | HTR1A (0.50) | DRD2MEN1KMT2AHTR1A | |
| SCHEMBL6159547 | 0.71 | PARK7 (0.36) | MEN1KMT2AHTR1A | |
| SCHEMBL19562130 | 0.70 | SLC6A4 (0.52) | SIGMAR1 | |
| SCHEMBL18753408 | 0.70 | SIGMAR1 (0.50) | SIGMAR1MEN1KMT2ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498344-B2 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | ASUBIO PHARMA CO., LTD. (JP) | 2009-03-03 | — | — | US | disclosed |
| US-7498344-B2 | Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same | ASUBIO PHARMA CO., LTD. (JP) | 2009-03-03 | — | — | US | disclosed |