Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947591 | 0.85 | MMP13 (0.68) | LMNAPOLBMAPK14MMP13CYP3A4 | |
| SCHEMBL13932522 | 0.83 | ALDH1A1 (0.78) | LMNAPOLBMAPK14HTTSMN1; SMN2 | |
| SCHEMBL12215290 | 0.82 | NPC1 (0.74) | LMNAMAPK14HTTSMN1; SMN2MMP13 | |
| SCHEMBL29602052 | 0.79 | ACACB (0.53) | LMNAPOLBHTTSMN1; SMN2ATM | |
| SCHEMBL24190676 | 0.79 | HTT (0.72) | LMNAPOLBHTTSMN1; SMN2ATM | |
| SCHEMBL6357065 | 0.79 | LMNA (0.70) | LMNAPOLBMAPK14HTTALDH1A1 | |
| SCHEMBL10099594 | 0.79 | LMNA (0.70) | LMNAPOLBMAPK14HTTALDH1A1 | |
| SCHEMBL31061058 | 0.79 | MAPK14 (1.00) | LMNAMAPK14HTTSMN1; SMN2MMP13 | |
| SCHEMBL13947386 | 0.78 | ALDH1A1 (0.66) | LMNAPOLBMAPK14HTTSMN1; SMN2 | |
| SCHEMBL24690107 | 0.78 | LMNA (0.66) | LMNAPOLBMAPK14HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090029990-A1 | Dihydropteridinones in the treatment of respiratory diseases | MAIER UDO | 2009-01-29 | — | — | US | disclosed |
| US-20070043055-A1 | Dihydropteridinones in the treatment of respiratory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043055-A1 | Dihydropteridinones in the treatment of respiratory diseases | QDPR, DHPS, NDUFS6 | LMNA 2051/4885POLB 3804/4885MAPK14 4305/4885 |
| US-20090029990-A1 | Dihydropteridinones in the treatment of respiratory diseases | QDPR, DHPS, NDUFS6 | LMNA 2051/4885POLB 3804/4885MAPK14 4305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.