Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | PRKX | P51817 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947362 | 0.85 | LMNA (0.68) | MMP13MAPK14LMNAPOLBCYP3A4 | |
| SCHEMBL13940425 | 0.85 | MMP13 (0.90) | MMP13MAPK14ROCK2ROCK1LMNA | |
| SCHEMBL27913637 | 0.85 | ROCK2 (0.66) | MMP13MAPK14ROCK2ROCK1LMNA | |
| SCHEMBL3031965 | 0.82 | HDAC8 (0.60) | MMP13MAPK14ROCK2ROCK1LMNA | |
| SCHEMBL14009845 | 0.81 | ROCK2 (0.54) | MMP13MAPK14ROCK2ROCK1CYP3A4 | |
| SCHEMBL10194841 | 0.80 | MMP13 (0.61) | MMP13MAPK14ROCK2LMNAPOLB | |
| SCHEMBL22995143 | 0.79 | ALDH1A1 (0.55) | MMP13ROCK2ROCK1POLBALDH1A1 | |
| SCHEMBL31036960 | 0.79 | ALDH1A1 (0.55) | MMP13ROCK2ROCK1POLBALDH1A1 | |
| SCHEMBL5213931 | 0.78 | ROCK2 (0.54) | MMP13MAPK14ROCK2ROCK1LMNA | |
| SCHEMBL2002841 | 0.78 | MEP1B (0.52) | MMP13MAPK14ROCK2ROCK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090029990-A1 | Dihydropteridinones in the treatment of respiratory diseases | MAIER UDO | 2009-01-29 | — | — | US | disclosed |
| US-20070043055-A1 | Dihydropteridinones in the treatment of respiratory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043055-A1 | Dihydropteridinones in the treatment of respiratory diseases | QDPR, DHPS, NDUFS6 | MMP13 3128/4885MAPK14 4305/4885ROCK2 2630/4885 |
| US-20090029990-A1 | Dihydropteridinones in the treatment of respiratory diseases | QDPR, DHPS, NDUFS6 | MMP13 3128/4885MAPK14 4305/4885ROCK2 2630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.