Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LAP3 | P28838 | 2/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515200 | 0.81 | OPRM1 (0.40) | OPRM1SPHK1TP53LAP3GRIK1 | |
| SCHEMBL13411321 | 0.78 | OPRM1 (0.50) | OPRM1SPHK1TP53LAP3GRIK1 | |
| SCHEMBL3454555 | 0.77 | SPHK1 (0.47) | OPRM1SPHK1TP53LAP3GRIK1 | |
| SCHEMBL28092875 | 0.77 | OPRM1 (0.55) | OPRM1SPHK1TP53LAP3GRIK1 | |
| SCHEMBL7149711 | 0.76 | SMPD1 (0.45) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| SCHEMBL3694779 | 0.75 | OPRM1 (0.52) | OPRM1SPHK1TP53LAP3GRIK1 | |
| SCHEMBL27221680 | 0.75 | OPRM1 (0.52) | OPRM1SPHK1TP53LAP3GRIK1 | |
| SCHEMBL28458489 | 0.75 | OPRM1 (0.52) | OPRM1SPHK1TP53LAP3GRIK1 | |
| SCHEMBL10521286 | 0.75 | — | — | |
| SCHEMBL11301482 | 0.73 | OPRM1 (0.50) | OPRM1SPHK1TP53LAP3GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11415576-B2 | Method for measurement of vitamin D | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2022-08-16 | — | — | US | disclosed |
| CN-107003305-B | Method for measuring vitamin D | 豪夫迈·罗氏有限公司 | 2021-04-02 | — | — | CN | disclosed |
| EP-3230739-B1 | METHOD FOR MEASUREMENT OF VITAMIN D | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| EP-3230739-A1 | METHOD FOR MEASUREMENT OF VITAMIN D | F. Hoffmann-La Roche AG (CH) | 2017-10-18 | — | — | EP | disclosed |
| US-20170269068-A1 | METHOD FOR MEASUREMENT OF VITAMIN D | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2017-09-21 | — | — | US | disclosed |
| WO-2016091755-A1 | METHOD FOR MEASUREMENT OF VITAMIN D | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-16 | — | — | WO | disclosed |
| US-7910363-B1 | Lipophilic polyamines providing enhanced intracellular delivery of agents by a polyamine transport system | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2011-03-22 | — | — | US | disclosed |
| EP-1441224-B1 | ENZYME INHIBITION IMMUNOASSAY | ROCHE DIAGNOSTICS GMBH (DE) | 2011-03-02 | — | — | EP | disclosed |
| US-7476727-B2 | Conjugates of mycophenolic acid | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2009-01-13 | — | — | US | disclosed |
| EP-1105730-B1 | ENZYME INHIBITION IMMUNOASSAY | ROCHE DIAGNOSTICS OPERATIONS (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20040076979-A1 | Dye pair for flourescence resonance energy transfer (fret) measurements | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2004-04-22 | — | — | US | disclosed |
| US-20030207431-A1 | Enzyme inhibition immunoassay | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2003-11-06 | — | — | US | disclosed |
| EP-1337851-A1 | DYE PAIR FOR FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) MEASUREMENTS | Roche Diagnostics GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| US-6524808-B1 | Combining analyte with ligand-inhibitor conjugate comprising ligand of analyte and an uncompetitive inhibitor of IMPDH, a receptor specific for said analyte, IMP, NAD and IMPDH; NADH production indicates presence or amount of analyte | ROCHE DIAGNOSTICS CORPORATION | 2003-02-25 | — | — | US | disclosed |
| WO-2002041001-A1 | DYE PAIR FOR FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) MEASUREMENTS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-05-23 | — | — | WO | disclosed |
| EP-1105730-A1 | ENZYME INHIBITION IMMUNOASSAY | Roche Diagnostics Corporation (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2001001135-A1 | ENZYME INHIBITION IMMUNOASSAY | ROCHE DIAGNOSTICS CORPORATION (US) | 2001-01-04 | — | — | WO | disclosed |
| US-6027885-A | MONONUCLEOSIDE TRIPHOSPHATE WITH AN ELECTROCHEMILUMINESCENCE GROUP; FOR DETECTION AND CHAIN EXTENSION OF OLIGONUCLEOTIDES | ROCHE DIAGNOSTICS GMBH (DE) | 2000-02-22 | — | — | US | disclosed |
| US-5639609-A | HYBRIDIZING WITH CAPTURE PROBE PROTECTED AGAINST ENZYMATIC DEGRADATION | BOEHRINGER MANNHEIM GMBH (DE) | 1997-06-17 | — | — | US | disclosed |
| EP-0628568-A2 | Method for the immobilisation of nucleic acids | Roche Diagnostics GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11415576-B2 | Method for measurement of vitamin D | CYP24A1, VDR, CYP2R1 | OPRM1 4289/4885SPHK1 3220/4885TP53 3743/4885 |
| US-20030207431-A1 | Enzyme inhibition immunoassay | IDE, RNASE1, SHBG | OPRM1 3052/4885SPHK1 3887/4885TP53 3625/4885 |
| US-20170269068-A1 | METHOD FOR MEASUREMENT OF VITAMIN D | CYP24A1, VDR, CYP2R1 | OPRM1 4289/4885SPHK1 3220/4885TP53 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.