Sugi Predict

Sugi Predict / Compounds / SCHEMBL409005

SCHEMBL409005

SCHEMBL409005

NC1CCN(C(=O)c2ccccc2)CC1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 1/20 0.69
▸ EPHX1 P07099 1/20 0.63
▸ L3MBTL3 Q96JM7 1/20 0.63
▸ L3MBTL1 Q9Y468 1/20 0.63
▸ HPGD P15428 1/20 0.61
▸ SMN1; SMN2 Q16637 1/20 0.58
▸ SIGMAR1 Q99720 1/20 0.58
▸ MEN1 O00255 2/20 0.56
▸ KMT2A Q03164 2/20 0.56
▸ MGLL Q99685 1/20 0.56
▸ HSD11B1 P28845 1/20 0.56
▸ ALDH1A1 P00352 2/20 0.54
▸ USP2 O75604 1/20 0.54
▸ CA12 O43570 1/20 0.54
▸ CA1 P00915 1/20 0.54
▸ CA2 P00918 1/20 0.54
▸ CA7 P43166 1/20 0.54
▸ CA9 Q16790 1/20 0.54
▸ CA14 Q9ULX7 1/20 0.54
▸ KDM4E B2RXH2 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4618202 0.98 ACHE (0.67) ACHEEPHX1L3MBTL3L3MBTL1HPGD
SCHEMBL14218322 0.93 HPGD (0.64) ACHEEPHX1L3MBTL3L3MBTL1HPGD
Trifluoroacetic Acid SCHEMBL5146749 0.91 ACHE (0.58) ACHEEPHX1L3MBTL3L3MBTL1HPGD
SCHEMBL1136719 0.90 L3MBTL3 (0.59) ACHEL3MBTL3L3MBTL1HPGDSMN1; SMN2
SCHEMBL2130912 0.89 ACHE (0.60) ACHEEPHX1L3MBTL3L3MBTL1HPGD
Hydrochloric Acid SCHEMBL1136918 0.89 L3MBTL3 (0.58) ACHEL3MBTL3L3MBTL1HPGDSMN1; SMN2
Bromide SCHEMBL1136932 0.89 L3MBTL3 (0.58) ACHEL3MBTL3L3MBTL1HPGDSMN1; SMN2
Hydrochloric Acid SCHEMBL7937513 0.88 ACHE (0.58) ACHEEPHX1L3MBTL3L3MBTL1HPGD
Hydrochloric Acid SCHEMBL7937517 0.88 ACHE (0.58) ACHEEPHX1L3MBTL3L3MBTL1HPGD
SCHEMBL10983933 0.87 ACHE (0.71) ACHEEPHX1L3MBTL3L3MBTL1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8354444-B2 Substituted pyrrolidine-2-carboxamides HOFFMANN-LA ROCHE INC. (US) 2013-01-15 — — US claimed
EP-2340021-B1 SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES HOFFMANN LA ROCHE (CH) 2012-11-07 — — EP claimed
US-20100152190-A1 Substituted Pyrrolidine-2-Carboxamides F. HOFFMANN-LA ROCHE AG (CH) 2010-06-17 — — US claimed
US-20100075948-A1 Substituted Pyrrolidine-2-Carboxamides DING QINGJIE 2010-03-25 — — US claimed
EP-1546150-B1 PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES AMURA THERAPEUTICS LTD (GB) 2009-03-04 — — EP claimed
EP-1121372-B1 ADENINE DERIVATIVES PFIZER LTD (GB) 2006-06-28 — — EP claimed
US-20040142999-A1 Novel compounds and compositions as cathepsin inhibitors AVENTIS PHARMACEUTICALS INC. (US) 2004-07-22 — — US claimed
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 — — EP claimed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 — — WO claimed
US-6326359-B1 PURINE DERIVATIVES PFIZER INC 2001-12-04 — — US claimed
EP-1121372-A1 ADENINE DERIVATIVES Pfizer Limited (GB) 2001-08-08 — — EP claimed
WO-2000023457-A1 ADENINE DERIVATIVES PFIZER LIMITED (GB) 2000-04-27 — — WO claimed
US-20240246964-A1 SUBSTITUTED 1-ARYL-1’-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1’-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-25 — — US disclosed
US-20240124412-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF GILEAD SCIENCES, INC. 2024-04-18 — — US disclosed
EP-4313968-A2 SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME Arbutus Biopharma Corporation (CA) 2024-02-07 — — EP disclosed
CN-117412959-A Substituted 1-aryl-1 '-heteroaryl compounds, substituted 1,1' -biaryl compounds, and methods of use thereof 爱彼特生物制药公司 2024-01-16 — — CN disclosed
EP-1121372-A1 ADENINE DERIVATIVES Pfizer Limited (GB) 2001-08-08 — — EP disclosed
EP-1008592-A2 Cyclic amide derivatives which inhibit cathepsin K Fujirebio Kabushiki Kaisha (JP) 2000-06-14 — — EP disclosed
WO-2000023457-A1 ADENINE DERIVATIVES PFIZER LIMITED (GB) 2000-04-27 — — WO disclosed
US-5216165-A N-substituted aminoquinolines as analgesic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1993-06-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100152190-A1 Substituted Pyrrolidine-2-Carboxamides ARG2, CCNY, PYCR1 ACHE 3153/4885EPHX1 3073/4885L3MBTL3 1338/4885
US-20240124412-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF IKZF2, IKZF1, IKZF3 ACHE 3804/4885EPHX1 2829/4885L3MBTL3 959/4885
US-20240246964-A1 SUBSTITUTED 1-ARYL-1’-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1’-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME HAVCR2, HDGF, HCCS ACHE 4471/4885EPHX1 931/4885L3MBTL3 684/4885
US-20100075948-A1 Substituted Pyrrolidine-2-Carboxamides ARG2, CCNY, PYCR1 ACHE 3153/4885EPHX1 3073/4885L3MBTL3 1338/4885
US-20040142999-A1 Novel compounds and compositions as cathepsin inhibitors CTSS, CTSB, CTSE ACHE 1043/4885EPHX1 2078/4885L3MBTL3 4303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.