Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229139 | 0.86 | MTNR1A (0.48) | PKM | |
| SCHEMBL14200380 | 0.85 | NOTUM (0.47) | NOTUMPKMALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL28974127 | 0.80 | ACE (0.59) | — | |
| SCHEMBL7593171 | 0.77 | NOTUM (0.57) | NOTUMPKMALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5556232 | 0.76 | PKM (0.51) | NOTUMPKMALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL14756252 | 0.74 | POLB (0.56) | ALDH1A1CYP2C19MEN1CYP3A4KMT2A | |
| SCHEMBL7067724 | 0.73 | MTNR1A (0.43) | PKMALDH1A1MEN1KMT2A | |
| SCHEMBL27968682 | 0.73 | NOTUM (0.52) | NOTUMPKMALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7993369 | 0.73 | DRD2 (0.54) | NOTUMPKMALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9204053 | 0.73 | NOTUM (0.64) | NOTUMPKMALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |