Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425049 | 0.88 | RAB9A (0.42) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL5802987 | 0.82 | TSHR (0.55) | KDM4ELMNAPOLBL3MBTL1TDP1 | |
| SCHEMBL9078315 | 0.76 | CA1 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL29580776 | 0.75 | CA1 (0.36) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3653725 | 0.69 | — | — | |
| SCHEMBL4362470 | 0.69 | — | — | |
| Phosphoric Acid Monomethyl Ester SCHEMBL9424981 | 0.68 | CA1 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6522079 | 0.68 | TDP1 (0.57) | LMNAGAATDP1MAPTALDH1A1 | |
| SCHEMBL666091 | 0.68 | CA12 (0.52) | CA12CA1CA2CA7CA9 | |
| SCHEMBL147169 | 0.68 | CA1 (0.71) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230026348-A1 | NITROXYLATED PROTEINS AND METHODS FOR THE USE THEREOF | SCHINDLER, WILLIAM | 2023-01-26 | — | — | US | disclosed |
| US-11359004-B2 | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins | Schindler, William (US) | 2022-06-14 | — | — | US | disclosed |
| US-11298407-B2 | Hemoglobin based oxygen carrier and method of preparation | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-04-12 | — | — | US | disclosed |
| EP-2968597-B1 | POLYALKYLENE OXIDE VALERATE HEMOGLOBIN CONJUGATES | SCHINDLER WILLIAM (US) | 2021-08-18 | — | — | EP | disclosed |
| US-10821158-B2 | Polyalkylene oxide valerate hemoglobin conjugates | Schindler, William (US) | 2020-11-03 | — | — | US | disclosed |
| US-20190127445-A1 | SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS | SCHINDLER, WILLIAM | 2019-05-02 | — | — | US | disclosed |
| EP-2834329-B1 | SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS | SCHINDLER WILLIAM (US) | 2018-10-17 | — | — | EP | disclosed |
| WO-2018053634-A1 | HEMOGLOBIN BASED OXYGEN CARRIER AND METHOD OF PREPARATION | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2018-03-29 | — | — | WO | disclosed |
| WO-2017197499-A1 | STABILIZED HEMOGLOBIN-AVIDIN ASSEMBLY AND METHOD OF PREPARATION | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-11-23 | — | — | WO | disclosed |
| US-20160022783-A1 | POLYALKYLENE OXIDE VALERATE HEMOGLOBIN CONJUGATES | SCHINDLER, WILLIAM | 2016-01-28 | — | — | US | disclosed |
| WO-1998037909-A9 | METHODS AND COMPOSITIONS FOR OPTIMIZATION OF OXYGEN TRANSPORT BY CELL-FREE SYSTEMS | UNIV CALIFORNIA (US) | 1999-11-18 | — | — | WO | disclosed |
| US-5917020-A | CROSSLINKING REAGENT FOR PROTEIN MODIFICATION | KLUGER RONALD H (CA) | 1999-06-29 | — | — | US | disclosed |
| EP-0669940-B1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | UNIV TORONTO (CA) | 1999-02-10 | — | — | EP | disclosed |
| US-5811521-A | Multifunctional crosslinking reagents for hemoglobin, and crosslinked hemoglobin conjugates | KLUGER RONALD H (CA) | 1998-09-22 | — | — | US | disclosed |
| WO-1998037909-A1 | METHODS AND COMPOSITIONS FOR OPTIMIZATION OF OXYGEN TRANSPORT BY CELL-FREE SYSTEMS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-09-03 | — | — | WO | disclosed |
| EP-0785920-A1 | MULTIFUNCTIONAL CROSS-LINKING REAGENTS FOR HEMOGLOBIN, AND CROSS-LINKED HEMOGLOBIN CONJUGATES | KLUGER, Ronald (CA) | 1997-07-30 | — | — | EP | disclosed |
| WO-1997000236-A1 | MULTIFUNCTIONAL CROSS-LINKING REAGENTS FOR HEMOGLOBIN, AND CROSS-LINKED HEMOGLOBIN CONJUGATES | KLUGER RONALD (CA) | 1997-01-03 | — | — | WO | disclosed |
| EP-0669940-A1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | THE UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION (CA) | 1995-09-06 | — | — | EP | disclosed |
| US-5399671-A | Specifically crosslinked hemoglobin with free functionality | UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION, THE (CA) | 1995-03-21 | — | — | US | disclosed |
| WO-1994011399-A1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | KLUGER RONALD (CA) | 1994-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022783-A1 | POLYALKYLENE OXIDE VALERATE HEMOGLOBIN CONJUGATES | HBZ, HBB, HBG1 | CA12 540/4885CA1 2040/4885CA2 1297/4885 |
| US-10821158-B2 | Polyalkylene oxide valerate hemoglobin conjugates | HBZ, HBB, HBG1 | CA12 540/4885CA1 2040/4885CA2 1297/4885 |
| US-20190127445-A1 | SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS | PPOX, QSOX1, HMOX2 | CA12 1440/4885CA1 2608/4885CA2 1380/4885 |
| US-11298407-B2 | Hemoglobin based oxygen carrier and method of preparation | HBZ, HBB, HBG2 | CA12 1018/4885CA1 1753/4885CA2 361/4885 |
| US-20230026348-A1 | NITROXYLATED PROTEINS AND METHODS FOR THE USE THEREOF | PPOX, MB, HMOX2 | CA12 1933/4885CA1 3350/4885CA2 2043/4885 |
| US-11359004-B2 | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins | PPOX, QSOX1, HMOX2 | CA12 1440/4885CA1 2608/4885CA2 1380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.