Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 6/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | USP2 | O75604 | 7/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23624902 | 0.86 | KEAP1 (0.62) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL16085240 | 0.84 | KEAP1 (0.60) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL22099930 | 0.84 | KEAP1 (0.60) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL12660523 | 0.83 | KEAP1 (0.61) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL28118369 | 0.82 | KEAP1 (0.60) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL14329988 | 0.82 | MEN1 (0.43) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL20385847 | 0.81 | KEAP1 (0.61) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL19872904 | 0.80 | USP2 (0.68) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL9437193 | 0.76 | KMT2A (0.78) | KEAP1NFE2L2TLR9KMT2AMEN1 | |
| SCHEMBL18470154 | 0.76 | ALDH1A1 (0.57) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212189-B2 | Fluorescent probes for reactive sulfur species | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212189-B2 | Fluorescent probes for reactive sulfur species | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-12-15 | — | — | US | disclosed |
| US-20120329085-A1 | FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120329085-A1 | FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329085-A1 | FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES | SQOR, CBS, CTH | KEAP1 93/4885NFE2L2 337/4885TLR9 4550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.