SCHEMBL143958

SCHEMBL143958

O=[C]C=Cc1cccc2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 1/20 0.53
▸ HDAC8 Q9BY41 1/20 0.50
▸ HDAC6 Q9UBN7 1/20 0.50
▸ MTNR1A P48039 1/20 0.49
▸ MTNR1B P49286 1/20 0.49
▸ CHAT P28329 4/20 0.46
▸ ALDH1A1 P00352 1/20 0.45
▸ CYP1A1 P04798 1/20 0.45
▸ CYP1A2 P05177 1/20 0.45
▸ CYP2D6 P10635 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ HPGD P15428 1/20 0.45
▸ NPY1R P25929 1/20 0.45
▸ MAPK1 P28482 1/20 0.45
▸ NPY2R P49146 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ CYP1B1 Q16678 1/20 0.45
▸ KDM4E B2RXH2 2/20 0.44
▸ RAB9A P51151 2/20 0.44
▸ LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3721694 1.00 RXRA (0.53) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL7189905 0.89 HPRT1 (0.48) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL7176899 0.83 ALDH1A1 (0.44) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL10706700 0.80 CHAT (0.62) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL10706687 0.80 CHAT (0.62) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL3811810 0.80 LMNA (0.41) ALDH1A1MAPTHPGDSMN1; SMN2KDM4E
SCHEMBL10706694 0.80 CHAT (0.62) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL7358330 0.80 RXRA (0.49) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL22029544 0.80 RXRA (0.49) RXRAHDAC8HDAC6MTNR1AMTNR1B
SCHEMBL10437274 0.78 CHAT (0.60) RXRAHDAC8HDAC6MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 742 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112470046-B Retardation film and method for producing same 林特琅普股份有限公司 2023-04-28 — — CN claimed
CN-112470046-A Retardation film and method for producing same 林特琅普股份有限公司 2021-03-09 — — CN claimed
WO-2020026632-A1 PHASE CONTRAST FILM AND PRODUCTION METHOD THEREFOR 林テレンプ株式会社 2020-02-06 — — WO claimed
US-7375081-B2 Therapeutic combination of a pneumocandin derivative and an antifungal agent ASTELLAS PHARMA INC. (JP) 2008-05-20 — — US claimed
US-6875740-B1 Combination of a cyclic hexapeptide with antifungal drugs for treatment of fungal pathogens FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 2005-04-05 — — US claimed
CN-117836290-A Synthesis method of bilirubin 株式会社毕丽斯 2024-04-05 — — CN disclosed
US-20240084308-A1 FIBROTIC TREATMENT MONASH UNIVERSITY (AU) 2024-03-14 — — US disclosed
US-20240034845-A1 POLYMER PARTICLES QUEENSLAND UNIVERSITY OF TECHNOLOGY (AU) 2024-02-01 — — US disclosed
EP-3384549-B1 SODIUM-ION ELECTROLYTE COMPOSITION UNIV DEAKIN (AU) 2024-01-17 — — EP disclosed
CN-117186081-A Main body material and preparation method thereof, double main body material and organic electroluminescent device 吉林奥来德光电材料股份有限公司 2023-12-08 — — CN disclosed
US-11834663-B2 Fibrotic treatment MONASH UNIVERSITY (AU) 2023-12-05 — — US disclosed
US-20230348674-A1 HYDROGELS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2023-11-02 — — US disclosed
WO-1992012154-A1 IMIDAZOTRIAZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-07-23 — — WO disclosed
WO-1992003438-A1 TRICYCLIC BENZODIAZEPINE DERIVATES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-03-05 — — WO disclosed
WO-1992002513-A1 HETEROCYCLIC COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-02-20 — — WO disclosed
US-4981847-A Tricyclic compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-01-01 — — US disclosed
EP-0360079-A1 Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-03-28 — — EP disclosed
EP-0336230-A2 Cyclic peptide antagonists of Substance P and Substance K FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-10-11 — — EP disclosed
EP-0022188-B1 CO-INITIATOR COMPOSITIONS FOR PHOTOPOLYMERIZATION CONTAINING 3-ACYL-SUBSTITUTED COUMARINS, PHOTOPOLYMERIZABLE COMPOSITION AND PHOTOGRAPHIC ELEMENT EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1984-10-03 — — EP disclosed
EP-0022188-A2 Co-initiator compositions for photopolymerization containing 3-acyl-substituted coumarins, photopolymerizable composition and photographic element EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1981-01-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11834663-B2 Fibrotic treatment MMP1, ENPEP, RNPEP RXRA 2486/4885HDAC8 1479/4885HDAC6 1004/4885
US-20230348674-A1 HYDROGELS PHYKPL, TST, PHOSPHO1 RXRA 4359/4885HDAC8 3350/4885HDAC6 1441/4885
US-20240084308-A1 FIBROTIC TREATMENT MMP1, ENPEP, RNPEP RXRA 2486/4885HDAC8 1479/4885HDAC6 1004/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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