Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.61 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.60 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.60 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.50 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL50511 | 0.93 | FFAR3 (0.77) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Propionic Acid SCHEMBL2454431 | 0.89 | FFAR3 (0.83) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Succinic Acid SCHEMBL16415716 | 0.89 | EGLN1 (0.75) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Propionic Acid SCHEMBL608914 | 0.89 | FFAR3 (0.83) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Succinic Acid SCHEMBL2148509 | 0.89 | EGLN1 (0.75) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Propionic Acid SCHEMBL386699 | 0.89 | FFAR3 (0.83) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Succinic Acid SCHEMBL35204 | 0.89 | EGLN1 (0.75) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Propionic Acid SCHEMBL2461940 | 0.89 | FFAR3 (0.83) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Propionic Acid SCHEMBL4328390 | 0.89 | FFAR3 (0.83) | FFAR3LMNASLC15A2EGLN1ALKBH5 | |
| Propionic Acid SCHEMBL35071 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207264-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | ESSA PHARMA INC. (CA) | 2024-06-27 | — | — | US | claimed |
| EP-4322933-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | ESSA PHARMA INC. (CA) | 2024-02-21 | — | — | EP | claimed |
| EP-4084778-B1 | AMORPHOUS KINASE INHIBITOR FORMULATIONS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS LLC (US) | 2023-11-01 | — | — | EP | claimed |
| EP-4214183-A1 | PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | Essa Pharma, Inc. (CA) | 2023-07-26 | — | — | EP | claimed |
| EP-4084779-A1 | COMPOSITIONS OF 1-(4-BROMO-5-(1-ETHYL-7-(METHYLAMINO)-2-OXO-1,2-DIHYDRO-1,6-NAPHTHYRIDIN-3-YL)-2-FLUOROPHENYL)-3-PHENYLUREA | Deciphera Pharmaceuticals, LLC (US) | 2022-11-09 | — | — | EP | claimed |
| US-20220105093-A1 | PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | ESSA PHARMACEUTICALS CORP. (CA) | 2022-04-07 | — | — | US | claimed |
| WO-2021138485-A1 | COMPOSITIONS OF 1-(4-BROMO-5-(1-ETHYL-7-(METHYLAMINO)-2-OXO-1,2-DIHYDRO-1,6-NAPHTHYRIDIN-3-YL)-2-FLUOROPHENYL)-3-PHENYLUREA | DECIPHERA PHARMACEUTICALS, LLC (US) | 2021-07-08 | — | — | WO | claimed |
| WO-2021138483-A1 | AMORPHOUS KINASE INHIBITOR FORMULATIONS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2021-07-08 | — | — | WO | claimed |
| EP-3171864-B1 | NANOPARTICLE FORMULATIONS OF LOW-WATER SOLUBILITY ACTIVES | BEND RES INC (US) | 2020-11-25 | — | — | EP | claimed |
| WO-2020099937-A2 | DIHYDROMYRICETIN SPRAY-DRIED DISPERSION FORMULATIONS AND METHODS FOR FORMING THEM | PRUD'HOMME, ROBERT, K. (US) | 2020-05-22 | — | — | WO | claimed |
| WO-2010102065-A1 | PHARMACEUTICAL COMPOSITIONS OF DEXTRAN POLYMER DERIVATIVES | BEND RESEARCH, INC. (US) | 2010-09-10 | — | — | WO | claimed |
| US-20100215747-A1 | NANOPARTICLES COMPRISING IONIZABLE, POORLY WATER SOLUBLE CELLULOSIC POLYMERS | BEND RESEARCH, INC. | 2010-08-26 | — | — | US | claimed |
| EP-2178518-A2 | NANOPARTICLES COMPRISING IONIZABLE, POORLY WATER SOLUBLE CELLULOSIC POLYMERS | Bend Research, Inc (US) | 2010-04-28 | — | — | EP | claimed |
| WO-2009010842-A2 | NANOPARTICLES COMPRISING IONIZABLE, POORLY WATER SOLUBLE CELLULOSIC POLYMERS | PFIZER PRODUCTS INC. (US) | 2009-01-22 | — | — | WO | claimed |
| EP-1874276-A2 | CELLULOSIC FILMS INCORPORATING A PHARMACEUTICALLY ACCEPTABLE PLASTICIZER WITH ENHANCED WETTABILITY | EASTMAN CHEMICAL COMPANY (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006115712-A2 | CELLULOSIC FILMS INCORPORATING A PHARMACEUTICALLY ACCEPTABLE PLASTICIZER WITH ENHANCED WETTABILITY | EASTMAN CHEMICAL COMPANY (US) | 2006-11-02 | — | — | WO | claimed |
| US-20060240108-A1 | Cellulosic films incorporating a pharmaceutically acceptable plasticizer with enhanced wettability | EASTMAN CHEMICAL COMPANY | 2006-10-26 | — | — | US | claimed |
| EP-0631604-A1 | AQUEOUS COATINGS COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | EASTMAN CHEMICAL COMPANY (US) | 1995-01-04 | — | — | EP | claimed |
| US-5286768-A | Aqueous coatings composition contianing cellulose mixed ester and amine neutralized acrylic resin and the process for the preparation thereof | EASTMAN KODAK COMPANY (US) | 1994-02-15 | — | — | US | claimed |
| WO-1993019136-A1 | AQUEOUS COATINGS COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | EASTMAN CHEMICAL COMPANY (US) | 1993-09-30 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100215747-A1 | NANOPARTICLES COMPRISING IONIZABLE, POORLY WATER SOLUBLE CELLULOSIC POLYMERS | CEL, GYS1, TNNC1 | FFAR3 1664/4885LMNA 2147/4885SLC15A2 243/4885 |
| US-20240207264-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | AR, NR5A1, SHBG | FFAR3 222/4885LMNA 3567/4885SLC15A2 2862/4885 |
| US-20220105093-A1 | PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF | AR, SHBG, NR3C2 | FFAR3 402/4885LMNA 3834/4885SLC15A2 3838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.