SCHEMBL14418348

SCHEMBL14418348

Nc1ccc2cc(S(=O)(=O)O)cc(O)c2c1/N=N/c1ccc(-c2ccc(/N=N/c3c(N)ccc4cc(S(=O)(=O)O)cc(O)c34)cc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SUMO2 P61956 2/20 0.72
▸ SUMO1 P63165 2/20 0.72
▸ SENP7 Q9BQF6 2/20 0.72
▸ SENP2 Q9HC62 2/20 0.72
▸ ENPP2 Q13822 5/20 0.68
▸ APEX1 P27695 2/20 0.51
▸ CYP1A2 P05177 2/20 0.50
▸ CYP2C9 P11712 2/20 0.50
▸ NT5E P21589 2/20 0.50
▸ CYP2C19 P33261 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ PHLPP2 Q6ZVD8 3/20 0.48
▸ PRMT1 Q99873 1/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ CDK1 P06493 1/20 0.43
▸ CDK2 P24941 1/20 0.43
▸ SENP3 Q9H4L4 1/20 0.43
▸ SENP1 Q9P0U3 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26459720 1.00 SUMO2 (0.72) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL26459322 0.94 SUMO2 (0.65) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL25511892 0.94 SUMO2 (0.65) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL11765859 0.94 SUMO2 (0.81) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL11765850 0.94 SUMO2 (0.81) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL10941468 0.93 SUMO2 (0.72) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL10941472 0.93 SUMO2 (0.72) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL11670234 0.91 SUMO2 (0.74) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL11670202 0.90 SUMO2 (0.72) SUMO2SUMO1SENP7SENP2ENPP2
SCHEMBL7790539 0.90 SENP2 (0.68) SUMO2SUMO1SENP7SENP2ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230148436-A2 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF SHENZHEN UNIVERSITY (CN) 2023-05-11 — — US disclosed
US-20210038605-A1 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF UNIV SHENZHEN (CN) 2021-02-11 — — US disclosed
US-7264932-B2 Nuclease inhibitor cocktail APPLERA CORPORATION (US) 2007-09-04 — — US disclosed
US-20070032418-A1 Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same AMBION, INC (US) 2007-02-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230148436-A2 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF IFNG, IFNAR1, STING1 SUMO2 466/4885SUMO1 605/4885SENP7 2975/4885
US-20070032418-A1 Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same RNASE1, RNASEH1, RNASEL SUMO2 3330/4885SUMO1 3284/4885SENP7 1438/4885
US-20210038605-A1 NOVEL SMALL MOLECULE IMMUNE AGONISTS AND IMMUNE TARGETING COMPOUNDS AND APPLICATION THEREOF IFNG, IFNAR1, STING1 SUMO2 466/4885SUMO1 605/4885SENP7 2975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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