SCHEMBL14507293

SCHEMBL14507293

COc1ccc(Cl)cc1C(=O)NCc1ccc(C(=O)NC(C)C)cc1

nearest known ligand 0.62

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.60
PPARA Q07869 3/20 0.59
ALDH1A1 P00352 1/20 0.58
DNMT3A Q9Y6K1 1/20 0.57
PTGER4 P35408 1/20 0.53
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
RAB9A P51151 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
HDAC1 Q13547 1/20 0.53
HDAC6 Q9UBN7 1/20 0.53
PPARD Q03181 1/20 0.53
NLRP3 Q96P20 3/20 0.52
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23657593 0.88 LMNA (0.72) LMNAPPARAALDH1A1DNMT3AHDAC1
SCHEMBL11464602 0.87 PTGER4 (0.69) LMNAPPARAALDH1A1DNMT3APTGER4
SCHEMBL11516368 0.85 LMNA (0.68) LMNAPPARAALDH1A1DNMT3AHDAC1
SCHEMBL14507295 0.83 DNMT3A (0.56) LMNAPPARAALDH1A1DNMT3APTGER4
SCHEMBL14507292 0.83 HPGD (0.71) LMNAALDH1A1RAB9ASMN1; SMN2HDAC1
SCHEMBL12838811 0.82 ALDH1A1 (0.76) LMNAALDH1A1DNMT3AMEN1KMT2A
SCHEMBL11356211 0.82 LMNA (0.64) LMNAPPARADNMT3APTGER4HDAC1
SCHEMBL17339437 0.81 LMNA (0.62) LMNAPPARAALDH1A1DNMT3AHDAC1
SCHEMBL29617795 0.81 LMNA (0.62) LMNAPPARAALDH1A1DNMT3AHDAC1
SCHEMBL11706059 0.81 DNMT3A (0.72) LMNAPPARADNMT3AHDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070124839-A1 Active substances for increasing the stress defense in plants to abiotic stress, and methods of finding them BAYER CROPSCIENCE GMBH (DE) 2007-05-31 US disclosed
US-20070015661-A1 Herbicide/safener combination BAYER CROPSCIENCE GMBH (DE) 2007-01-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015661-A1 Herbicide/safener combination CBR3, CBR1, GSR LMNA 3838/4885PPARA 1514/4885ALDH1A1 630/4885
US-20070124839-A1 Active substances for increasing the stress defense in plants to abiotic stress, and methods of finding them HSF1, HSPA2, HSPA8 LMNA 4564/4885PPARA 2238/4885ALDH1A1 3979/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.