SCHEMBL145288

SCHEMBL145288

COC(=O)c1ccc(N)cc1Cl

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.66
ABL1 P00519 1/20 0.59
CHRM2 P08172 1/20 0.56
CHRM3 P20309 1/20 0.56
MAOA P21397 1/20 0.56
HTR2C P28335 1/20 0.56
CHRNA4 P43681 1/20 0.56
HTR3A P46098 1/20 0.56
KCNH2 Q12809 1/20 0.56
HRH3 Q9Y5N1 1/20 0.56
NR1H4 Q96RI1 1/20 0.52
ALDH1A1 P00352 5/20 0.51
KDM4E B2RXH2 4/20 0.51
HSD17B10 Q99714 3/20 0.51
GLA P06280 2/20 0.51
MAPT P10636 2/20 0.51
HPGD P15428 2/20 0.51
CASP1 P29466 1/20 0.51
CASP7 P55210 1/20 0.51
ATM Q13315 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3865922 0.98 GAA (0.64) GAAABL1CHRM2CHRM3MAOA
SCHEMBL1761427 0.86 GAA (0.54) GAAABL1CHRM2CHRM3MAOA
SCHEMBL57389 0.85 GAA (0.61) GAAABL1ALDH1A1KDM4EHSD17B10
Hydrochloric Acid SCHEMBL5389504 0.84 GAA (0.59) GAAABL1ALDH1A1KDM4EHSD17B10
SCHEMBL1403643 0.82 GAA (0.72) GAAABL1ALDH1A1KDM4EHSD17B10
SCHEMBL2884923 0.81 PDK2 (0.57) GAAABL1ALDH1A1KDM4EHSD17B10
SCHEMBL7623605 0.81 GAA (0.70) GAAABL1ALDH1A1KDM4EHSD17B10
SCHEMBL29400478 0.81 GAA (0.70) GAAABL1ALDH1A1KDM4EHSD17B10
SCHEMBL2926607 0.81 GAA (0.70) GAAABL1ALDH1A1KDM4EHSD17B10
SCHEMBL608814 0.81 ABL1 (0.68) ABL1ALDH1A1KDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 644 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094953-A 1, 3-Dihydro-2H-pyrrolo [3,4-c ] quinoline derivatives as cGAS inhibitors for the treatment of inflammatory and/or autoimmune diseases 2026-05-26 CN disclosed
US-20260124222-A1 ISOTHIAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY HOTSPOT THERAPEUTICS INC (US) 2026-05-07 US disclosed
WO-2026087442-A1 AMINO-IMIDAZOLE ANTIBACTERIAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2026-04-30 WO disclosed
EP-4161931-B1 NOVEL IMIDAZOPYRAZINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2026-02-18 EP disclosed
CN-121537689-A Rubber sealing strip and preparation method thereof 河北利耐尔橡塑制品有限公司 2026-02-17 CN disclosed
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2025-12-25 US disclosed
US-20250353862-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2025-11-20 US disclosed
EP-4640678-A1 NOVEL OXO-PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF Chengdu Shibeikang Biomedical Technology Co., Ltd. (CN) 2025-10-29 EP disclosed
US-12448388-B2 PRMT5 inhibitors and uses thereof GILEAD SCIENCES, INC. (US) 2025-10-21 US disclosed
US-20250206713-A1 2-[(2-OXO-4-PHENYL-2H-CHROMEN-7-YL)OXY] PROPANAMIDO DERIVATIVES LUNELLA BIOTECH, INC. (CA) 2025-06-26 US disclosed
WO-1996022293-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1996-07-25 WO disclosed
US-5536718-A Tricyclic benzazepine vasopressin antagonists AMERICAN CYANAMID COMPANY (US) 1996-07-16 US disclosed
US-5532235-A TO TREAT EXCESS RENAL REABSORPTION AMERICAN CYANAMID COMPANY (US) 1996-07-02 US disclosed
EP-0682656-A1 USE OF PHENYL HETEROARYL UREAS AS 5HT 2C? RECEPTOR ANTAGONISTS AND UREA COMPOUNDS SMITHKLINE BEECHAM PLC (GB) 1995-11-22 EP disclosed
WO-1994018170-A1 USE OF PHENYL HETEROARYL UREAS AS 5HT2C RECEPTOR ANTAGONISTS AND UREA COMPOUNDS SMITHKLINE BEECHAM PLC (GB) 1994-08-18 WO disclosed
WO-1993008188-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1993-04-29 WO disclosed
WO-1991012000-A1 ANILINE DERIVATIVES OF α-STYRYL CARBINOLS AS ANTIFUNGAL AGENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-08-22 WO disclosed
US-4293566-A FUNGICIDES, BACTERICIDES, INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1981-10-06 US disclosed
US-4183949-A Pesticidally active 1-arylamino-2,4-dinitronaphthalenes BAYER AKTIENGESELLSCHAFT (DE) 1980-01-15 US disclosed
US-4094636-A DIAZOTIZATION HOECHST AKTIENGESELLSCHAFT (DT) 1978-06-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT1, PRMT5, PRMT6 GAA 4402/4885ABL1 874/4885CHRM2 2572/4885
US-20250353862-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 GAA 3895/4885ABL1 1967/4885CHRM2 4885/4885
US-12448388-B2 PRMT5 inhibitors and uses thereof PRMT5, PRMT1, PRMT9 GAA 3048/4885ABL1 1147/4885CHRM2 4479/4885
US-20250206713-A1 2-[(2-OXO-4-PHENYL-2H-CHROMEN-7-YL)OXY] PROPANAMIDO DERIVATIVES POLRMT, TFAM, POLM GAA 4375/4885ABL1 4072/4885CHRM2 1675/4885
US-20260124222-A1 ISOTHIAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY MALT1, BCL6, BCL6B GAA 4303/4885ABL1 758/4885CHRM2 3413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.