SCHEMBL1456975

SCHEMBL1456975

Fc1c(Cl)ncnc1Oc1ccccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
GPR119 Q8TDV5 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HTT P42858 1/20 0.41
MAP4K4 O95819 1/20 0.40
MRGPRX1 Q96LB2 4/20 0.39
SLC6A2 P23975 3/20 0.39
HTR1A P08908 2/20 0.39
SLC6A4 P31645 2/20 0.39
SLC6A3 Q01959 2/20 0.39
LMNA P02545 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
TRPA1 O75762 2/20 0.38
TRPC5 Q9UL62 1/20 0.38
EGFR P00533 2/20 0.38
ADRB2 P07550 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30374325 1.00 KMT2A (0.50) KMT2AMEN1GPR119ALDH1A1HTT
SCHEMBL5196093 0.87 KMT2A (0.50) KMT2AMEN1GPR119ALDH1A1HTT
SCHEMBL3370619 0.86 MEN1 (0.41) KMT2AMEN1GPR119ALDH1A1MRGPRX1
SCHEMBL12825466 0.85 KMT2A (0.49) KMT2AMEN1GPR119ALDH1A1HTT
SCHEMBL16378820 0.85 KMT2A (0.56) KMT2AMEN1GPR119ALDH1A1HTT
SCHEMBL22057360 0.84 KMT2A (0.48) KMT2AMEN1GPR119ALDH1A1HTT
SCHEMBL24540615 0.80 PIN1 (0.46) GPR119MAP4K4MRGPRX1LMNATRPC5
SCHEMBL1456728 0.79 TRPA1 (0.45) KMT2AMEN1MRGPRX1L3MBTL1TRPA1
SCHEMBL5083809 0.78 KMT2A (0.43) KMT2AMEN1GPR119ALDH1A1HTT
SCHEMBL1457337 0.78 KMT2A (0.43) KMT2AMEN1GPR119ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12559483-B2 Process for the preparation of fluoxastrobin and intermediates thereof UPL LTD (IN) 2026-02-24 US disclosed
US-12024492-B2 Process for preparation of azoxystrobin and intermediates thereof UPL LTD (IN) 2024-07-02 US disclosed
US-12024492-B2 Process for preparation of azoxystrobin and intermediates thereof UPL LTD (IN) 2024-07-02 US disclosed
US-11952350-B2 Process for the preparation of fungicidally active strobilurin compounds and intermediates thereof UPL LTD. (IN) 2024-04-09 US disclosed
EP-3303312-B1 PROCESS FOR PREPARING (E)-(5,6-DIHYDRO-1,4,2-DIOXAZINE-3-YL)(2-HYDROXYPHENYL)METHANONE O-METHYL OXIME ARYSTA LIFESCIENCE CORP (JP) 2023-07-19 EP disclosed
EP-3303312-B1 PROCESS FOR PREPARING (E)-(5,6-DIHYDRO-1,4,2-DIOXAZINE-3-YL)(2-HYDROXYPHENYL)METHANONE O-METHYL OXIME ARYSTA LIFESCIENCE CORP (JP) 2023-07-19 EP disclosed
US-20230219940-A1 PROCESS FOR THE PREPARATION OF FLUOXASTROBIN AND INTERMEDIATES THEREOF UPL LTD (IN) 2023-07-13 US disclosed
US-20230219940-A1 PROCESS FOR THE PREPARATION OF FLUOXASTROBIN AND INTERMEDIATES THEREOF UPL LTD (IN) 2023-07-13 US disclosed
US-20230219940-A1 PROCESS FOR THE PREPARATION OF FLUOXASTROBIN AND INTERMEDIATES THEREOF UPL LTD (IN) 2023-07-13 US disclosed
CN-115916774-A Process for the preparation of fluoxastrobin and intermediates thereof UPL有限公司 2023-04-04 CN disclosed
EP-1268446-B1 METHOD FOR PRODUCING ASYMMETRICAL 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2010-10-06 EP disclosed
EP-0970057-B1 SUBSTITUTED AMINOSALICYCLIC ACID AMIDES WITH FUNGICIDAL EFFECT AND INTERMEDIATE PRODUCTS FOR PRODUCTION THEREOF BAYER CROPSCIENCE AG (DE) 2006-02-01 EP disclosed
EP-1533303-A1 Substituted Aminosalicylacid Amides ( intermediates ) Bayer CropScience AG (DE) 2005-05-25 EP disclosed
US-6734304-B2 REACTING THE CORRESPONDING 4.6-DIHALOPYRIMIDINE COMPOUND WITH BASE; ONE POT PROCESS BAYER AKTIENGESELLSCHAFT (DE) 2004-05-11 US disclosed
US-20030092723-A1 Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2003-05-15 US disclosed
EP-1268446-A1 METHOD FOR PRODUCING ASYMMETRICAL 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES Bayer CropScience AG (DE) 2003-01-02 EP disclosed
US-6380386-B2 INSECTICIDES, BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 2002-04-30 US disclosed
US-20020006958-A1 Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2002-01-17 US disclosed
WO-2001072719-A1 METHOD FOR PRODUCING ASYMMETRICAL 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2001-10-04 WO disclosed
US-6194418-B1 Substituted aminosalicyclic acid amides with fungicidal effect and intermediate products for production thereof BAYER AKTIENGESELLSCHAFT (DE) 2001-02-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030092723-A1 Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives DPYD, TYMS, TYMP KMT2A 2163/4885MEN1 4310/4885GPR119 4165/4885
US-11952350-B2 Process for the preparation of fungicidally active strobilurin compounds and intermediates thereof TYR, CYP51A1, STS KMT2A 3922/4885MEN1 924/4885GPR119 3433/4885
US-20020006958-A1 Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof AADAC, DDC, DAO KMT2A 1930/4885MEN1 2410/4885GPR119 1744/4885
US-20230219940-A1 PROCESS FOR THE PREPARATION OF FLUOXASTROBIN AND INTERMEDIATES THEREOF P2RX6, SI, DCPS KMT2A 4479/4885MEN1 1973/4885GPR119 892/4885
US-12024492-B2 Process for preparation of azoxystrobin and intermediates thereof NISCH, STS, SNX2 KMT2A 3991/4885MEN1 914/4885GPR119 1273/4885
US-12559483-B2 Process for the preparation of fluoxastrobin and intermediates thereof P2RX7, P2RX6, CTRB1 KMT2A 4777/4885MEN1 2389/4885GPR119 1450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.