Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14595719 | 0.94 | ALDH1A1 (0.46) | TACR3ELANEALDH1A1KMT2AKDM4E | |
| SCHEMBL14595742 | 0.94 | ADAMTS4 (0.45) | TACR3ADAMTS4MMP13LMNASMN1; SMN2 | |
| SCHEMBL14595745 | 0.93 | MMP13 (0.40) | TACR3ELANEALDH1A1KMT2AKDM4E | |
| SCHEMBL14595723 | 0.93 | CA12 (0.44) | TACR3ELANEKMT2AKDM4EADAMTS4 | |
| SCHEMBL14595728 | 0.93 | ALDH1A1 (0.47) | ALDH1A1KMT2AKDM4EADAMTS4MMP13 | |
| SCHEMBL14595718 | 0.93 | KMT2A (0.41) | TACR3ELANEALDH1A1KMT2AKDM4E | |
| SCHEMBL14595725 | 0.92 | OPRK1 (0.42) | TACR3ELANEALDH1A1KMT2AADAMTS4 | |
| SCHEMBL14595748 | 0.92 | MMP9 (0.48) | TACR3ELANEALDH1A1ADAMTS4MMP13 | |
| SCHEMBL14595722 | 0.92 | CACNA1G (0.43) | TACR3ELANEALDH1A1KDM4EADAMTS4 | |
| SCHEMBL14595726 | 0.92 | MEP1B (0.43) | ALDH1A1KMT2AADAMTS4LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015774-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-01-18 | — | — | US | disclosed |
| US-20070015774-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015774-A1 | Quinazoline derivatives useful in cancer treatment | TP53, TP53BP1, ACIN1 | TACR3 3301/4885ELANE 1019/4885ALDH1A1 1994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.