Acrylic Acid

Acrylic Acid

SCHEMBL1461885

C=CC(=O)O.C=CC(N)=O.[H+].[Na+]

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.69
ALDH1A1 P00352 2/20 0.69
FGFR4 P22455 1/20 0.69
LMNA P02545 1/20 0.62
ALOX15 P16050 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ACHE P22303 1/20 0.35
LDHA P00338 1/20 0.32
LDHB P07195 1/20 0.32
TP53 P04637 1/20 0.32
EGLN1 Q9GZT9 1/20 0.32
EGLN3 Q9H6Z9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylic Acid SCHEMBL28962045 0.97 ALDH1A1 (0.73) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL8499374 0.97 ALDH1A1 (0.73) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL8500826 0.97 ALDH1A1 (0.73) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL10675286 0.94 ALDH1A1 (0.79) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL7140121 0.94 ALDH1A1 (0.79) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL26086 0.94 ALDH1A1 (0.79) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL10927263 0.94 ALDH1A1 (0.79) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL202523 0.90 ALDH1A1 (0.73) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL11854987 0.90 ALDH1A1 (0.73) TSHRALDH1A1FGFR4LMNAALOX15
Acrylic Acid SCHEMBL202522 0.90 ALDH1A1 (0.73) TSHRALDH1A1FGFR4LMNAALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011027335-A9 YEAST CELL IMMOBILIZATION UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG (ZA) 2011-05-05 WO disclosed
WO-2011027335-A1 YEAST CELL IMMOBILIZATION UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG (ZA) 2011-03-10 WO disclosed