SCHEMBL14645951

SCHEMBL14645951

CC1=Cc2c(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)ccc(C)c2[CH]1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RXRB P28702 5/20 0.36
RXRA P19793 4/20 0.33
RXRG P48443 2/20 0.33
POLB P06746 1/20 0.32
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27952594 0.94 RXRB (0.36) RXRBRXRARXRGPOLBKDM4E
SCHEMBL27663765 0.85 TSHR (0.36) POLBKDM4E
SCHEMBL15810239 0.82 TDO2 (0.33) RXRB
SCHEMBL1241864 0.76 RXRB (0.36) RXRBRXRARXRGKDM4EGAA
SCHEMBL21381466 0.76 TSHR (0.40) POLBKDM4E
SCHEMBL28860851 0.75 RXRB (0.35) RXRBRXRARXRG
SCHEMBL28198733 0.75 RXRB (0.35) RXRBRXRARXRG
SCHEMBL14645582 0.73 KDM4E (0.33) RXRBRXRARXRGPOLBKDM4E
SCHEMBL14645947 0.72 RXRB (0.34) RXRBRXRARXRGPOLB
SCHEMBL19644561 0.72 RXRA (0.33) RXRBRXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3131935-B1 NEW CATALYST SYSTEM FOR PRODUCING POLYETHYLENE COPOLYMERS IN A HIGH TEMPERATURE SOLUTION POLYMERIZATION PROCESS BOREALIS AG (AT) 2020-06-03 EP disclosed
US-10301411-B2 Catalyst system for producing polyethylene copolymers in a high temperature solution polymerization process BOREALIS AG (AT) 2019-05-28 US disclosed
EP-2746301-B1 Catalyst BOREALIS AG (AT) 2018-05-30 EP disclosed
EP-2729479-B1 CATALYSTS BOREALIS AG (AT) 2017-09-06 EP disclosed
US-9630980-B2 Asymmetrical ligands BOREALIS AG (AT) 2017-04-25 US disclosed
US-9598517-B2 Catalysts BOREALIS AG (AT) 2017-03-21 US disclosed
US-20170037164-A1 NEW CATALYST SYSTEM FOR PRODUCING POLYETHYLENE COPOLYMERS IN A HIGH TEMPERATURE SOLUTION POLYMERIZATION PROCESS BOREALIS AG (AT) 2017-02-09 US disclosed
CN-105377915-A Process for the preparation of propylene copolymer containing higher alpha-olefins BOREALIS AG 2016-03-02 CN disclosed
US-20160024123-A1 Asymmetrical Ligands BOREALIS AG (AT) 2016-01-28 US disclosed
US-20150344596-A1 CATALYSTS BOREALIS AG (AT) 2015-12-03 US disclosed
US-9187583-B2 Catalysts BOREALIS AG (AT) 2015-11-17 US disclosed
EP-2933277-A1 New catalyst system for producing polyethylene copolymers in a high temperature solution polymerization process Borealis AG (AT) 2015-10-21 EP disclosed
US-20140221584-A1 CATALYSTS BOREALIS AG (AT) 2014-08-07 US disclosed
WO-2014096166-A1 CATALYSTS BOREALIS AG (AT) 2014-06-26 WO disclosed
EP-2746301-A1 Catalyst Borealis AG (AT) 2014-06-25 EP disclosed
EP-2729479-A1 CATALYSTS Borealis AG (AT) 2014-05-14 EP disclosed
CN-103649101-A Catalyst and process for preparing same BOREALIS AG 2014-03-19 CN disclosed
WO-2013007650-A1 CATALYSTS BOREALIS AG (AT) 2013-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10301411-B2 Catalyst system for producing polyethylene copolymers in a high temperature solution polymerization process RPS8, MLX, HRH2 RXRB 2801/4885RXRA 2019/4885RXRG 2501/4885
US-20170037164-A1 NEW CATALYST SYSTEM FOR PRODUCING POLYETHYLENE COPOLYMERS IN A HIGH TEMPERATURE SOLUTION POLYMERIZATION PROCESS RPS8, HRH2, MLX RXRB 2843/4885RXRA 2033/4885RXRG 2730/4885
US-20160024123-A1 Asymmetrical Ligands CCRL2, AR, CCR2 RXRB 599/4885RXRA 672/4885RXRG 482/4885
US-20150344596-A1 CATALYSTS SFN, AP3S1, H1-2 RXRB 585/4885RXRA 672/4885RXRG 473/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.