SCHEMBL146717

SCHEMBL146717

ClC(Cl)C(=Cc1ccccc1)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C1 Q04828 1/20 0.45
PRMT1 Q99873 1/20 0.41
ESR1 P03372 1/20 0.41
CYP19A1 P11511 2/20 0.39
CYP11B2 P19099 2/20 0.39
ALDH1A1 P00352 2/20 0.39
LMNA P02545 2/20 0.39
MAPT P10636 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.39
FBP1 P09467 1/20 0.38
TSHR P16473 1/20 0.38
AKR1C3 P42330 1/20 0.38
PLIN1 O60240 1/20 0.36
BCHE P06276 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10711205 1.00 AKR1C1 (0.45) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL8528509 0.80 AKR1C1 (0.47) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL2835097 0.78 AKR1C1 (0.45) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL5960470 0.78 AKR1C1 (0.45) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL4375040 0.77 L3MBTL1 (0.47) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL6227960 0.75 LMNA (0.48) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL4632474 0.75 LMNA (0.48) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL10630337 0.73 FBP1 (0.45) AKR1C1PRMT1ESR1ALDH1A1MAPT
SCHEMBL16500484 0.72 MEN1 (0.42) AKR1C1PRMT1ESR1CYP19A1CYP11B2
SCHEMBL11356886 0.72 AKR1C1 (0.40) AKR1C1PRMT1ESR1CYP19A1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120059137-A1 MONODISPERSE CHLOROMETHYLSTYRENE POLYMER AND PRODUCING METHOD THEREOF AGC SEIMI CHEMICAL CO., LTD. (JP) 2012-03-08 US disclosed