Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24091383 | 1.00 | HRH3 (0.37) | HRH3 | |
| SCHEMBL20711726 | 1.00 | HRH3 (0.37) | HRH3 | |
| SCHEMBL20711867 | 0.88 | DRD2 (0.34) | HRH3 | |
| SCHEMBL17827390 | 0.88 | DRD2 (0.34) | HRH3 | |
| SCHEMBL10121108 | 0.86 | HRH3 (0.42) | HRH3 | |
| SCHEMBL25004759 | 0.83 | HRH3 (0.35) | HRH3 | |
| SCHEMBL23992762 | 0.83 | HRH3 (0.35) | HRH3 | |
| SCHEMBL146590 | 0.81 | — | — | |
| SCHEMBL8121510 | 0.80 | HRH3 (0.38) | HRH3 | |
| SCHEMBL9963119 | 0.80 | HRH3 (0.38) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372496-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | US | disclosed |
| US-20230372496-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | US | disclosed |
| US-11667624-B2 | Indole compounds as androgen receptor modulators | NIDO BIOSCIENCES, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-10428080-B2 | TBK/IKK inhibitor compounds and uses thereof | MERCK PATENT GMBH (DE) | 2019-10-01 | — | — | US | disclosed |
| US-20190233390-A1 | NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USE THEREOF | Institute of Pharmacology and Toxicology Academy of Millitary Medical Sciences P.L.A. China (CN) | 2019-08-01 | — | — | US | disclosed |
| WO-2019144117-A1 | BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT | BIOVENTURES, LLC (US) | 2019-07-25 | — | — | WO | disclosed |
| US-10301279-B2 | Piperidine carboxamide compound, preparation method, and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-05-28 | — | — | US | disclosed |
| US-10196364-B2 | Pyrimidine carboxamides as sodium channel blockers | PURDUE PHARMA L.P. (US) | 2019-02-05 | — | — | US | disclosed |
| US-9988391-B2 | TBK/IKK inhibitor compounds and uses thereof | MERCK PATENT GMBH (DE) | 2018-06-05 | — | — | US | disclosed |
| US-9637458-B2 | Pyrimidine carboxamides as sodium channel blockers | PURDUE PHARMA L.P. | 2017-05-02 | — | — | US | disclosed |
| US-9637458-B2 | Pyrimidine carboxamides as sodium channel blockers | PURDUE PHARMA L.P. | 2017-05-02 | — | — | US | disclosed |
| US-20160376283-A1 | TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-12-29 | — | — | US | disclosed |
| US-9499862-B2 | Phospholinked dye analogs with an amino acid linker | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2016-11-22 | — | — | US | disclosed |
| US-20160318896-A1 | NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-03 | — | — | US | disclosed |
| US-20160009659-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2016-01-14 | — | — | US | disclosed |
| US-20150197794-A1 | Phospholinked Dye Analogs with an Amino Acid Linker | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| US-8993737-B2 | Phospholinked dye analogs with an amino acid linker | PACIFIC BIOSCIENCES, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20120058473-A1 | Molecular Adaptors for Dye Conjugates | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120052507-A1 | PHOSPHOLINKED DYE ANALOGS WITH AN AMINO ACID LINKER | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196364-B2 | Pyrimidine carboxamides as sodium channel blockers | CACNA1A, TRPV1, TRPA1 | HRH3 473/4885 |
| US-20230372496-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | CRBN, CDR2, MDM2 | HRH3 3345/4885 |
| US-20120052507-A1 | PHOSPHOLINKED DYE ANALOGS WITH AN AMINO ACID LINKER | CHAMP1, MTAP, INCENP | HRH3 3994/4885 |
| US-10428080-B2 | TBK/IKK inhibitor compounds and uses thereof | NFKBIA, TBKBP1, TBK1 | HRH3 4521/4885 |
| US-10301279-B2 | Piperidine carboxamide compound, preparation method, and use thereof | HSF1, HSP90AB1, HSPD1 | HRH3 1700/4885 |
| US-11667624-B2 | Indole compounds as androgen receptor modulators | AR, FSHR, ADRB3 | HRH3 1317/4885 |
| US-20160318896-A1 | NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USAGE THEREOF | HSF1, HSP90AB1, HSP90AA1 | HRH3 1587/4885 |
| US-20160009659-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | CACNA1A, TRPV1, TRPA1 | HRH3 443/4885 |
| US-20120058473-A1 | Molecular Adaptors for Dye Conjugates | ALKBH1, ALKBH5, ALKBH3 | HRH3 4257/4885 |
| US-20190233390-A1 | NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USE THEREOF | HSF1, HSP90AB1, HEATR1 | HRH3 1568/4885 |
| US-20150197794-A1 | Phospholinked Dye Analogs with an Amino Acid Linker | INCENP, CHAMP1, PNKP | HRH3 3903/4885 |
| US-20160376283-A1 | TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF | NFKBIA, TBKBP1, TBK1 | HRH3 4521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.