Thiomorpholinomethylenediphosphonic Acid

Thiomorpholinomethylenediphosphonic Acid

SCHEMBL1471965

O=P(O)(O)C(N1CCSCC1)P(=O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FDPS P14324 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thiomorpholinomethylenediphosphonic Acid SCHEMBL10345507 0.98 FDPS (0.95) FDPS
SCHEMBL10346154 0.92 FDPS (0.84) FDPS
Thiomorpholinomethylenediphosphonic Acid SCHEMBL10345508 0.86 FDPS (0.74) FDPS
SCHEMBL203348 0.82 FDPS (0.75) FDPS
SCHEMBL898693 0.82 FDPS (0.75) FDPS
SCHEMBL3080928 0.82 FDPS (0.75) FDPS
SCHEMBL2203676 0.77 FDPS (0.85) FDPS
SCHEMBL2472093 0.75 FDPS (1.00) FDPS
N-(Hexamethyleneimino)Methylenebisphosphonic Acid SCHEMBL12309768 0.75 FDPS (1.00) FDPS
SCHEMBL9356971 0.73 FDPS (0.62) FDPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7915239-B2 Treating lameness with an osseous and/or articular component which appear in a person or animal not suffering from fractures or arthritis; horses; veterinary medicine; bone disorders, osteoarthritis CEVA SANTE ANIMALE (FR) 2011-03-29 US claimed
EP-1120117-B1 Method of increasing the production of eggs and strengthening eggshells in poultry CEVA SANTE ANIMALE (FR) 2007-09-12 EP claimed
US-20060183717-A1 Process for treating lameness with an osseous, articular or osteoarticular component in human or veterinary medicine, comprising the administration of a bisphosphonic acid derivative CEVA SANTE ANIMALE 2006-08-17 US claimed
EP-1117410-B1 USE OF BISPHOSPHONIC ACID DERIVATIVES FOR PREPARING A MEDICINE FOR TREATING LAMENESS CEVA SANTE ANIMALE (FR) 2005-12-28 EP claimed
US-20040110726-A1 Process for treating lameness administration of a bisphosphonic acid derivative CEVA SANTE ANIMALE 2004-06-10 US claimed
US-6696429-B2 ESPECIALLY DUE TO OSTEOARTHROSIS, OSTEOCHONDROSIS, NAVICULAR DISEASE OR ENTHESOPATHY OF THE BONY INSERTIONS OF THE TENDONS, OF THE LIGAMENTS, OR OF THE APONEUROSIS, PARTICULARLY IN HORSES CEVA SANTE ANIMALE (FR) 2004-02-24 US claimed
US-20030032627-A1 Process for treating lameness by administration of a bisphosphonic acid derivative SANOFI SANTE NUTRITION ANIMALE 2003-02-13 US claimed
US-20030013685-A1 Process for increasing the egg production and strengthening the eggshells of poultry CEVA SANTE ANIMALE (FR) 2003-01-16 US claimed
US-6455514-B2 HUMAN OR VETERINARY MEDICINE, ESPECIALLY HORSES, INVOLVING LAMENESS WITH AN OSSEOUS, ARTICULAR OR OSTEOARTICULAR COMPONENT AND NOT INVOLVED WITH ARTHRITUS OR FRACTURES; NO INCREASE IN BONE DENSITY; E.G., TILUDRONIC ACID AND SALTS CEVA SANTE ANIMALE (FR) 2002-09-24 US claimed
EP-0623347-B1 Use of bisphosphoric acid derivatives for the manufacture of a medicament to improvement bone repair SANOFI SYNTHELABO (FR) 2001-10-31 EP claimed
US-20010006960-A1 PROCESS FOR TREATING LAMENESS BY ADMINISTRATION OF A BISPHOSPHONIC ACID DERIVATIVE CEVA SANTE ANIMALE (FR) 2001-07-05 US claimed
EP-0998934-A1 REMEDIES FOR INTRAMEDULLARY DISEASES TORAY INDUSTRIES, INC. (JP) 2000-05-10 EP claimed
EP-0336851-B1 PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION CONTAINING A DIPHOSPHONIC ACID DERIVATIVE ELF SANOFI (FR) 1992-03-18 EP claimed
US-4980171-A AND SODIUM LAURYL SULFATE; EXCELLENT BIOAVAILABILITY; BONE DISORSERS, ANTIARTHRETIC SOCIETE ANONYME DITE : SANOFI (FR) 1990-12-25 US claimed
EP-0248854-B1 NOVEL BISPHOSPHONIC DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1990-04-25 EP claimed
US-4870063-A Bisphosphonic acid derivatives, their production and use LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 1989-09-26 US claimed
EP-0276288-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A BISPHOSPHONATE AND THEIR USE FOR NASAL ADMINISTRATION LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1988-08-03 EP claimed
WO-1988000829-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A BISPHOSPHONATE AND THEIR USE FOR NASAL ADMINISTRATION LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LØVENS KEMIS (DK) 1988-02-11 WO claimed
EP-0248854-A1 NOVEL BISPHOSPHONIC DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION. LEO PHARM PROD LTD (DK) 1987-12-16 EP claimed
WO-1987003598-A1 NOVEL BISPHOSPHONIC DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 1987-06-18 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060183717-A1 Process for treating lameness with an osseous, articular or osteoarticular component in human or veterinary medicine, comprising the administration of a bisphosphonic acid derivative SLC16A1, SLC26A4, SLCO4C1 FDPS 703/4885
US-20030032627-A1 Process for treating lameness by administration of a bisphosphonic acid derivative SLC16A1, CLIC1, SLC16A3 FDPS 1138/4885
US-20010006960-A1 PROCESS FOR TREATING LAMENESS BY ADMINISTRATION OF A BISPHOSPHONIC ACID DERIVATIVE SLC16A1, CLIC1, SLC16A3 FDPS 1138/4885
US-20030013685-A1 Process for increasing the egg production and strengthening the eggshells of poultry ALPP, FABP6, BMP6 FDPS 298/4885
US-20040110726-A1 Process for treating lameness administration of a bisphosphonic acid derivative SLC16A1, SLC16A3, CLIC1 FDPS 1099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.