Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | PER2 | O15055 | 3/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720875 | 1.00 | FKBP1A (0.38) | FKBP1APER2SRD5A2CRY2AKR1C3 | |
| SCHEMBL14722282 | 0.84 | PER2 (0.36) | PER2SRD5A2CRY2AKR1C3KCNH2 | |
| SCHEMBL14720524 | 0.81 | PDE4A (0.35) | FKBP1APER2SRD5A2CRY2 | |
| SCHEMBL14720525 | 0.81 | PDE4A (0.35) | FKBP1APER2SRD5A2CRY2 | |
| SCHEMBL14720463 | 0.80 | L3MBTL1 (0.47) | SRD5A2KCNH2HRH3 | |
| SCHEMBL14721179 | 0.80 | L3MBTL1 (0.50) | SRD5A2HRH3 | |
| SCHEMBL14720825 | 0.80 | TP53 (0.46) | SRD5A2 | |
| SCHEMBL14720649 | 0.79 | FKBP1A (0.35) | FKBP1ASRD5A2HRH3 | |
| SCHEMBL14720643 | 0.78 | OPRM1 (0.41) | HRH3 | |
| SCHEMBL14722442 | 0.77 | GRM2 (0.47) | SRD5A2KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |