SCHEMBL147600

SCHEMBL147600

Fc1c[c]ccc1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 9/20 0.36
KDM1A O60341 1/20 0.32
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19356870 0.82
SCHEMBL101627 0.81 KIF11 (0.32) KIF11
SCHEMBL146460 0.80 AR (0.31)
SCHEMBL3031821 0.79
SCHEMBL15319301 0.79 CA2 (0.30)
SCHEMBL1958841 0.76
SCHEMBL17965388 0.76
SCHEMBL145184 0.74 NOTUM (0.33)
SCHEMBL1519797 0.74 AR (0.32) KIF11
SCHEMBL454798 0.74 AR (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1428 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113874353-B Microbiocidal derivatives 先正达农作物保护股份公司 2024-06-14 CN claimed
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME RAPPTA THERAPEUTICS OY (FI) 2024-05-30 US claimed
EP-3893645-B1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (CA) 2024-04-17 EP claimed
WO-2024073283-A1 HETEROCYCLES AS MODULATORS OF NSD ACTIVITY BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-04-04 WO claimed
EP-3750894-B1 UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) 2024-04-03 EP claimed
EP-4326721-A1 SPIROCYCLIC IMIDAZOLIDINONES AND IMIDAZOLIDINEDIONES FOR TREATMENT OF LIGHT CHAIN AMYLOIDOSIS Protego Biopharma, Inc. (US) 2024-02-28 EP claimed
US-11903936-B2 Anti-malarial agents THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-02-20 US claimed
US-20240051960-A1 SPIROCYCLIC IMIDAZOLIDINONES AND IMIDAZOLIDINEDIONES FOR TREATMENT OF LIGHT CHAIN AMYLOIDOSIS PROTEGO BIOPHARMA, INC. 2024-02-15 US claimed
EP-4077308-B1 ANTI-MALARIAL AGENTS UNIV TEXAS (US) 2024-02-14 EP claimed
EP-4288412-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME Rappta Therapeutics Oy (FI) 2023-12-13 EP claimed
US-20030109518-A1 Substituted 1,4-benzodiazepines and uses thereof ORTHO-MCNEIL PHARMACEUTICAL, INC. 2003-06-12 US claimed
WO-2003048156-A1 SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE Grünenthal GmbH (DE) 2003-06-12 WO claimed
US-20030105094-A1 MCH antagonists and their use in the treatment of obesity SCHERING CORPORATION 2003-06-05 US claimed
WO-2003041715-A1 SUBSTITUTED 1,4-BENZODIAZEPINES AND USES THEREOF FOR THE TREATMENT OF CANCER 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2003-05-22 WO claimed
WO-2002076947-A1 MCH ANTAGONISTS AND THEIR USE IN THE TREATMENT OF OBESITY SCHERING CORPORATION (US) 2002-10-03 WO claimed
EP-1049670-B1 AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS VERNALIS RES LTD (GB) 2002-07-17 EP claimed
EP-1196165-A2 AZETIDINE COMPOUNDS IN CNS AND EYE DISEASES VERNALIS RESEARCH LIMITED (GB) 2002-04-17 EP claimed
WO-2001007022-A2 AZETIDINE COMPOUNDS IN CNS AND EYE DISEASES VERNALIS RESEARCH LIMITED (GB) 2001-02-01 WO claimed
EP-1049670-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 2000-11-08 EP claimed
WO-1999037613-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 1999-07-29 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11903936-B2 Anti-malarial agents PYCR1, DHFR, QDPR KIF11 2138/4885KDM1A 1230/4885CYP11B1 197/4885
US-20240051960-A1 SPIROCYCLIC IMIDAZOLIDINONES AND IMIDAZOLIDINEDIONES FOR TREATMENT OF LIGHT CHAIN AMYLOIDOSIS IGLV6-57, TTR, MAP1LC3C KIF11 2969/4885KDM1A 4460/4885CYP11B1 3372/4885
US-20030105094-A1 MCH antagonists and their use in the treatment of obesity MCHR1, MCHR2, MC4R KIF11 3300/4885KDM1A 250/4885CYP11B1 394/4885
US-20240174603-A1 MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME PPM1A, PPP2CA, PPP3CA KIF11 4642/4885KDM1A 2185/4885CYP11B1 1282/4885
US-20030109518-A1 Substituted 1,4-benzodiazepines and uses thereof MDM2, CBR1, ADRM1 KIF11 2339/4885KDM1A 1431/4885CYP11B1 152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.