Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PPM1D | O15297 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28133767 | 0.84 | GPR84 (0.38) | PPM1DCA1CA2GAA | |
| SCHEMBL3547435 | 0.80 | PLA2G2A (0.46) | MRGPRX4TP53PKMNFKB1RAB9A | |
| SCHEMBL27975645 | 0.78 | DAO (0.45) | RAB9APPM1DKMT2A | |
| SCHEMBL28138572 | 0.76 | DAO (0.48) | RAB9APPM1DKMT2A | |
| SCHEMBL27999944 | 0.76 | RXRA (0.47) | MRGPRX4TP53PKMNFKB1RAB9A | |
| SCHEMBL57366 | 0.76 | RXRA (0.47) | MRGPRX4TP53PKMNFKB1RAB9A | |
| SCHEMBL14812309 | 0.76 | NR1H4 (0.49) | RXRAMEN1KMT2A | |
| SCHEMBL10472668 | 0.75 | PTGS2 (0.60) | CNR1CNR2MEN1KMT2AALDH1A1 | |
| SCHEMBL12480647 | 0.74 | RXRA (0.46) | MRGPRX4TP53PKMNFKB1RAB9A | |
| SCHEMBL5270681 | 0.74 | CA1 (0.47) | MRGPRX4TP53PKMNFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3292110-B1 | N-PIPERIDIN-4-YL DERIVATIVES | MERCK SHARP & DOHME (NL) | 2019-08-21 | — | — | EP | disclosed |
| EP-3292110-A1 | N-PIPERIDIN-4-YL DERIVATIVES | Merck Sharp & Dohme B.V. (NL) | 2018-03-14 | — | — | EP | disclosed |
| US-8993757-B2 | N-piperidin-4-yl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2015-03-31 | — | — | US | disclosed |
| US-20140329822-A1 | N-PIPERIDIN-4-YL DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2014-11-06 | — | — | US | disclosed |
| WO-2013041457-A1 | N-PIPERIDIN-4-YL DERIVATIVES | MSD OSS B.V. (NL) | 2013-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329822-A1 | N-PIPERIDIN-4-YL DERIVATIVES | PGR, CYP19A1, BRCA1 | MRGPRX4 2340/4885TP53 3049/4885PKM 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.