Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323608 | 0.82 | ALDH1A1 (0.36) | CA2CA12CA1CA9CHKA | |
| SCHEMBL17912781 | 0.82 | CA2 (0.35) | CA2CA12CA1CA9CHKA | |
| Hydrochloric Acid SCHEMBL626136 | 0.80 | ALDH1A1 (0.35) | CA2CA12CA1CA9CHKA | |
| SCHEMBL6632132 | 0.75 | ALDH1A1 (0.36) | CA2CHKASIGMAR1CHRM5CHRM3 | |
| SCHEMBL27610692 | 0.74 | CA2 (0.37) | CA2CA12CA1CA9CHKA | |
| SCHEMBL30802393 | 0.74 | CTSD (0.33) | CA2CA12CA1CA9SIGMAR1 | |
| SCHEMBL6632262 | 0.74 | SIGMAR1 (0.36) | CA2CA12CA1CA9CHKA | |
| SCHEMBL4058036 | 0.74 | SIGMAR1 (0.34) | CA2CA12CA1CA9CHKA | |
| SCHEMBL3024275 | 0.73 | PHGDH (0.31) | — | |
| SCHEMBL10748425 | 0.73 | HSD17B10 (0.37) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891985-B | Use of specific aminosilyl monomers in rubber manufacture | 盛禧奥欧洲有限责任公司 | 2023-02-17 | — | — | CN | disclosed |
| US-10954330-B2 | Use of specific aminosilyl monomers in the manufacture of rubber | TRINSEO EUROPE GMBH (CH) | 2021-03-23 | — | — | US | disclosed |
| US-20200377636-A1 | Use of Specific Aminosilyl Monomers in the Manufacture of Rubber | SYNTHOS DWORY 7 SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (PL) | 2020-12-03 | — | — | US | disclosed |
| CN-110891985-A | Use of specific aminosilyl monomers in rubber manufacture | 盛禧奥欧洲有限责任公司 | 2020-03-17 | — | — | CN | disclosed |
| WO-2019020752-A1 | USE OF SPECIFIC AMINOSILYL MONOMERS IN THE MANUFACTURE OF RUBBER | TRINSEO EUROPE GMBH (CH) | 2019-01-31 | — | — | WO | disclosed |
| EP-3434699-A1 | USE OF SPECIFIC AMINOSILYL MONOMERS IN THE MANUFACTURE OF RUBBER | Trinseo Europe GmbH (CH) | 2019-01-30 | — | — | EP | disclosed |
| EP-2468277-A1 | Triptolide derivatives for modulation of apoptosis and immunosuppression | Pharmagenesis, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |
| US-20110076293-A1 | TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION | DAI DONGCHENG | 2011-03-31 | — | — | US | disclosed |
| US-7847109-B2 | Triptolide derivatives for modulation of apoptosis and immunosuppression | PHARMAGENESIS, INC. (US) | 2010-12-07 | — | — | US | disclosed |
| US-7662976-B2 | Triptolide derivatives for modulation of apoptosis and immunosuppression | PHARMAGENESIS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090171103-A1 | Triptolide Derivatives for Modulation of Apoptosis and Immunosuppression | DAI DONGCHENG | 2009-07-02 | — | — | US | disclosed |
| EP-1511478-A2 | TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION | PHARMAGENESIS, INC. (US) | 2005-03-09 | — | — | EP | disclosed |
| US-20040235943-A1 | Triptolide derivatives for modulation of apoptosis and immunosuppression | PHARMAGENESIS, INC. | 2004-11-25 | — | — | US | disclosed |
| WO-2003101951-A2 | TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION | PHARMAGENESIS, INC. (US) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235943-A1 | Triptolide derivatives for modulation of apoptosis and immunosuppression | CASP7, CASP14, CASP3 | CA2 37/4885CA12 171/4885CA1 33/4885 |
| US-20090171103-A1 | Triptolide Derivatives for Modulation of Apoptosis and Immunosuppression | CASP7, CASP14, CASP3 | CA2 37/4885CA12 171/4885CA1 33/4885 |
| US-20110076293-A1 | TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION | CASP7, CASP14, CASP3 | CA2 37/4885CA12 171/4885CA1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.