Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.30 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.30 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477281 | 0.81 | ALDH1A1 (0.33) | — | |
| SCHEMBL1484414 | 0.74 | CA2 (0.38) | SIGMAR1CA2CA12CA1CA9 | |
| SCHEMBL27610692 | 0.68 | CA2 (0.37) | SIGMAR1CA2CA12CA1CA9 | |
| SCHEMBL6632262 | 0.68 | SIGMAR1 (0.36) | SIGMAR1CA2CA12CA1CA9 | |
| SCHEMBL4887482 | 0.66 | GAA (0.38) | SIGMAR1CA2CA12CA1CA9 | |
| SCHEMBL4745377 | 0.66 | CA2 (0.38) | SIGMAR1CA2CA12CA1CA9 | |
| SCHEMBL28199271 | 0.66 | CA2 (0.38) | SIGMAR1CA2CA12CA1CA9 | |
| Bicarbonate SCHEMBL6297564 | 0.66 | CA2 (0.38) | SIGMAR1CA2CA12CA1CA9 | |
| SCHEMBL30802393 | 0.64 | CTSD (0.33) | SIGMAR1CA2CA12CA1CA9 | |
| Hydrochloric Acid SCHEMBL25387507 | 0.64 | HPGD (0.40) | SIGMAR1CA2CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4406606-A2 | ANTIBODY DRUG CONJUGATES (ADCS) AND ANTIBODY PRODRUG CONJUGATES (APDCS) WITH ENZYMATICALLY CLEAVABLE G | Bayer Pharma Aktiengesellschaft (DE) | 2024-07-31 | — | — | EP | disclosed |
| US-20230203034-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2023-06-29 | — | — | US | disclosed |
| EP-2863920-B1 | QUINOLINE DERIVATIVES FOR USE IN THE TRATMENT OF BREAST CANCER | EUTROPICS PHARMACEUTICALS INC (US) | 2023-03-22 | — | — | EP | disclosed |
| US-11608338-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | MERCK PATENT GMBH (DE) | 2023-03-21 | — | — | US | disclosed |
| EP-3868761-B1 | IMIDAZOLONYLCHINOLINES AND THEIR USE AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2023-03-01 | — | — | EP | disclosed |
| US-20210198257-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2021-07-01 | — | — | US | disclosed |
| US-10975075-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | MERCK PATENT GMBH (DE) | 2021-04-13 | — | — | US | disclosed |
| EP-3560924-B1 | IMIDAZOLONYL QUINOLINES AND THEIR USE AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2021-03-31 | — | — | EP | disclosed |
| US-20200325137-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2020-10-15 | — | — | US | disclosed |
| CN-111747952-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-10-09 | — | — | CN | disclosed |
| WO-2016096610-A1 | ANTIBODY-DRUG CONJUGATES (ADCS) OF KSP INHIBITORS WITH AGLYCOSYLATED ANTI-TWEAKR ANTIBODIES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-23 | — | — | WO | disclosed |
| US-20150150869-A1 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES | EUTROPICS PHARMACEUTICALS, INC. | 2015-06-04 | — | — | US | disclosed |
| US-20150133450-A1 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES | EUTROPICS PHARMACEUTICALS INC (US) | 2015-05-14 | — | — | US | disclosed |
| EP-1513531-B1 | BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | MENARINI RICERCHE SPA (IT) | 2009-10-21 | — | — | EP | disclosed |
| US-7491825-B2 | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | MENARINI RICERCHE S.P.A. (IT) | 2009-02-17 | — | — | US | disclosed |
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20060205712-A1 | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | MENARINI RIEERCHE S.P.A. (IT) | 2006-09-14 | — | — | US | disclosed |
| EP-1513531-A1 | BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | Menarini Ricerche S.p.A. (IT) | 2005-03-16 | — | — | EP | disclosed |
| US-20040192698-A1 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. | 2004-09-30 | — | — | US | disclosed |
| WO-2003103671-A1 | BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM | MENARINI RICERCHE S.P.A. (IT) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150150869-A1 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES | BCL3, BCL6, MCL1 | SIGMAR1 4526/4885CA2 1931/4885CA12 2573/4885 |
| US-20230203034-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | SIGMAR1 4336/4885CA2 4788/4885CA12 4884/4885 |
| US-10975075-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | ATM, CHEK2, CHEK1 | SIGMAR1 4869/4885CA2 4517/4885CA12 4884/4885 |
| US-20060205712-A1 | Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom | BDKRB2, BDKRB1, AGTR2 | SIGMAR1 495/4885CA2 295/4885CA12 1659/4885 |
| US-20150133450-A1 | METHODS AND COMPOSITIONS USEFUL FOR TREATING DISEASES INVOLVING BCL-2 FAMILY PROTEINS WITH QUINOLINE DERIVATIVES | BCL3, BCL6, MCL1 | SIGMAR1 4526/4885CA2 1931/4885CA12 2573/4885 |
| US-20210198257-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | SIGMAR1 4336/4885CA2 4788/4885CA12 4884/4885 |
| US-20200325137-A1 | IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS | ATM, CHEK2, CHEK1 | SIGMAR1 4336/4885CA2 4788/4885CA12 4884/4885 |
| US-20040192698-A1 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | CYP4B1, CYP3A4, CYP1B1 | SIGMAR1 226/4885CA2 1715/4885CA12 4049/4885 |
| US-11608338-B2 | Imidazolonylquinolines and the use thereof as ATM kinase inhibitors | ATM, CHEK2, CHEK1 | SIGMAR1 4336/4885CA2 4788/4885CA12 4884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.