Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5786405 | 0.89 | AKR1C3 (0.55) | AKR1C3AKR1C2TRPA1TRPM8ROCK2 | |
| SCHEMBL10035005 | 0.88 | NOTUM (0.52) | AKR1C3AKR1C2TRPA1TRPM8PDK2 | |
| SCHEMBL14925354 | 0.82 | PDK2 (0.51) | AKR1C3AKR1C2PDK2ALDH1A1MAOA | |
| SCHEMBL14925356 | 0.82 | RXRA (0.55) | MAOAMAOBSMN1; SMN2NPC1 | |
| SCHEMBL881297 | 0.82 | LMNA (0.59) | L3MBTL1ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL14925368 | 0.81 | PDK2 (0.50) | AKR1C3AKR1C2TRPA1TRPM8PDK2 | |
| SCHEMBL11541429 | 0.81 | L3MBTL1 (0.49) | PDK2L3MBTL1ALDH1A1PDE4DMAPT | |
| SCHEMBL16838797 | 0.81 | KIF11 (0.51) | AKR1C3AKR1C2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL14925362 | 0.79 | MAOA (0.49) | AKR1C3AKR1C2TRPA1PDK2ALDH1A1 | |
| SCHEMBL10035086 | 0.78 | ALDH1A1 (0.54) | AKR1C3AKR1C2ALDH1A1PDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116227-A1 | BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116227-A1 | BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | MC2R, NR3C2, REN | AKR1C3 99/4885AKR1C2 131/4885TRPA1 3302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.