Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 5/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 8/20 | 0.48 |
| ▸ | MIF | P14174 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | BACH1 | O14867 | 1/20 | 0.42 |
| ▸ | MAFK | O60675 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1607282 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL5070755 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL1607124 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL1607149 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL14933787 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL25332541 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL1606718 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL106183 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| SCHEMBL2485837 | 1.00 | NAAA (0.54) | NAAATRPA1MIFGSK3BKEAP1 | |
| Sulforaphane SCHEMBL20855320 | 0.98 | NAAA (0.50) | NAAATRPA1MIFGSK3BKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210401791-A1 | METHODS AND COMPOSITIONS FOR REDUCING ALCOHOL TOXICITY | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-12-30 | — | — | US | disclosed |
| EP-2859890-A2 | Methods and compositions for treatment of autism | The Johns Hopkins University (US) | 2015-04-15 | — | — | EP | disclosed |
| US-20150087702-A1 | METHODS AND COMPOSITIONS FOR REDUCING ALCOHOL TOXICITY | UNIV JOHNS HOPKINS (US) | 2015-03-26 | — | — | US | disclosed |
| US-20150087702-A1 | METHODS AND COMPOSITIONS FOR REDUCING ALCOHOL TOXICITY | UNIV JOHNS HOPKINS (US) | 2015-03-26 | — | — | US | disclosed |
| US-20150051288-A1 | Methods and Compositions for Treatment of Autism | UNIV JOHNS HOPKINS (US) | 2015-02-19 | — | — | US | disclosed |
| US-8937050-B2 | Methods and compositions for treatment of autism | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-01-20 | — | — | US | disclosed |
| US-20130123203-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | KENNEDY KRIEGER INSTITUTE, INC. | 2013-05-16 | — | — | US | disclosed |
| WO-2013067040-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051288-A1 | Methods and Compositions for Treatment of Autism | CHAT, AHCY, SYNGR2 | NAAA 206/4885TRPA1 3820/4885MIF 4883/4885 |
| US-20210401791-A1 | METHODS AND COMPOSITIONS FOR REDUCING ALCOHOL TOXICITY | ADH1C, ADH1A, ADH5 | NAAA 896/4885TRPA1 4012/4885MIF 3920/4885 |
| US-20150087702-A1 | METHODS AND COMPOSITIONS FOR REDUCING ALCOHOL TOXICITY | ADH1C, ADH1A, ADH5 | NAAA 896/4885TRPA1 4012/4885MIF 3920/4885 |
| US-20130123203-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF AUTISM | CHAT, AHCY, SYNGR2 | NAAA 206/4885TRPA1 3820/4885MIF 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.