Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14937439 | 0.83 | RORC (0.43) | RORCCTSSMEN1KMT2ADHODH | |
| SCHEMBL21835728 | 0.81 | SMN1; SMN2 (0.39) | RORCCHRNA3MEN1KMT2ASLC6A4 | |
| SCHEMBL3756550 | 0.80 | ALDH1A1 (0.43) | RORCMAOBCHRNA3MEN1KMT2A | |
| SCHEMBL29754231 | 0.80 | RORC (0.34) | RORCMEN1KMT2ASLC6A4ALDH1A1 | |
| SCHEMBL4342358 | 0.77 | ALOX15 (0.42) | CHRNA3MEN1KMT2ASLC6A4LMNA | |
| SCHEMBL2105856 | 0.75 | RORC (0.45) | RORCMEN1KMT2ADHODHALDH1A1 | |
| SCHEMBL19962979 | 0.75 | MAOB (0.39) | MAOBCHRNA3MEN1KMT2ALMNA | |
| SCHEMBL19962980 | 0.75 | MAOB (0.39) | MAOBCHRNA3MEN1KMT2ALMNA | |
| SCHEMBL2833080 | 0.74 | LDHA (0.42) | RORCMEN1KMT2ASLC6A4LMNA | |
| SCHEMBL28778383 | 0.74 | MAPT (0.43) | RORCMEN1KMT2AKCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776392-B1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | HOFFMANN LA ROCHE (CH) | 2016-05-18 | — | — | EP | disclosed |
| EP-2776392-B1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | HOFFMANN LA ROCHE (CH) | 2016-05-18 | — | — | EP | disclosed |
| EP-2776392-A1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-17 | — | — | EP | disclosed |
| US-8796471-B2 | Process for the preparation of proline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796471-B2 | Process for the preparation of proline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| WO-2013068434-A1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-16 | — | — | WO | disclosed |
| US-20130123512-A1 | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130123512-A1 | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-05-16 | — | — | US | disclosed |
| WO-2013068434-A1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123512-A1 | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES | CTSS, CTSV, CTSZ | RORC 4425/4885MAOB 806/4885CTSS 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.