Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965756 | 0.88 | PKM (0.40) | SIGMAR1SMN1; SMN2 | |
| SCHEMBL14966168 | 0.86 | ALDH1A1 (0.40) | SIGMAR1SMN1; SMN2 | |
| SCHEMBL14965773 | 0.85 | L3MBTL1 (0.46) | SIGMAR1SMN1; SMN2 | |
| SCHEMBL14965902 | 0.82 | KDM4E (0.53) | SIGMAR1TMEM97SMN1; SMN2 | |
| SCHEMBL14966181 | 0.81 | KDM4E (0.56) | SIGMAR1TMEM97SMN1; SMN2 | |
| SCHEMBL14966188 | 0.80 | KDM4E (0.50) | SIGMAR1TMEM97SMN1; SMN2 | |
| SCHEMBL14971108 | 0.80 | ALDH1A1 (0.44) | SMN1; SMN2 | |
| SCHEMBL14965800 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2 | |
| SCHEMBL14965407 | 0.79 | KCNJ1 (0.42) | SMN1; SMN2 | |
| SCHEMBL14965777 | 0.78 | HIF1A (0.58) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |