Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682640 | 0.85 | HAO1 (0.43) | HAO1KCNH2HRH3CASP1BACE1 | |
| SCHEMBL16216729 | 0.83 | SLC6A2 (0.44) | HAO1TNK2OPRM1OPRD1OPRK1 | |
| SCHEMBL21628783 | 0.80 | OPRK1 (0.53) | OPRM1OPRD1OPRK1 | |
| SCHEMBL21628396 | 0.80 | OPRK1 (0.53) | OPRM1OPRD1OPRK1 | |
| SCHEMBL554256 | 0.80 | ALDH1A1 (0.54) | HAO1KCNH2HRH3BACE1SLC18A3 | |
| SCHEMBL21104547 | 0.79 | ALDH1A1 (0.52) | MAPK14HSPB1 | |
| SCHEMBL21628791 | 0.79 | OPRK1 (0.54) | OPRM1OPRD1OPRK1 | |
| SCHEMBL21628462 | 0.79 | KMO (0.49) | HAO1OPRM1OPRD1OPRK1CASP1 | |
| SCHEMBL21628714 | 0.79 | KMO (0.49) | HAO1OPRM1OPRD1OPRK1CASP1 | |
| SCHEMBL9075126 | 0.78 | TEAD4 (0.36) | MAPK14OPRM1OPRD1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210382038-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2021-12-09 | — | — | US | claimed |
| CN-113616648-A | Notch signaling pathway inhibitors and their use in cancer treatment | 洛桑联邦理工学院(EPFL) | 2021-11-09 | — | — | CN | claimed |
| US-20190219566-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2019-07-18 | — | — | US | claimed |
| EP-3332783-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) | 2018-06-13 | — | — | EP | claimed |
| EP-2793884-B1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2017-11-29 | — | — | EP | claimed |
| US-9296682-B2 | Inhibitors of notch signalling pathway and use thereof in treatment of cancers | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2016-03-29 | — | — | US | claimed |
| EP-3332783-B1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2024-12-04 | — | — | EP | disclosed |
| CN-119019324-A | Process for preparing aminodiaryl ethers and aminodiaryl ether hydrochlorides | 塞莱斯蒂亚生物技术股份公司 | 2024-11-26 | — | — | CN | disclosed |
| US-12030855-B2 | Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts | CELLESTIA BIOTECH AG (CH) | 2024-07-09 | — | — | US | disclosed |
| US-20220388961-A1 | PROCESS FOR MAKING AMINO DIARYL ETHERS AND AMINO DIARYL ETHERS HYDROCHLORIDE SALTS | CELLESTIA BIOTECH AG (CH) | 2022-12-08 | — | — | US | disclosed |
| US-11472771-B2 | Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts | CELLESTIA BIOTECH AG (CH) | 2022-10-18 | — | — | US | disclosed |
| US-20220185793-A1 | COMPOUNDS FOR THE TREATMENT OF ONCOVIRUS INDUCED CANCER AND METHODS OF USE THEREOF | CELLESTIA BIOTECH AG (CH) | 2022-06-16 | — | — | US | disclosed |
| EP-3952997-A1 | COMPOUNDS FOR THE TREATMENT OF ONCOVIRUS INDUCED CANCER AND METHODS OF USE THEREOF | Cellestia Biotech AG (CH) | 2022-02-16 | — | — | EP | disclosed |
| US-9296682-B2 | Inhibitors of notch signalling pathway and use thereof in treatment of cancers | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2016-03-29 | — | — | US | disclosed |
| US-20140329867-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2014-11-06 | — | — | US | disclosed |
| US-20140329867-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2014-11-06 | — | — | US | disclosed |
| US-20140329867-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2014-11-06 | — | — | US | disclosed |
| EP-2793884-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Ecole Polytechnique Federale de Lausanne (EPFL) (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013093885-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Ecole polytechnique fédérale de Lausanne (EPFL) (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013093885-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Ecole polytechnique fédérale de Lausanne (EPFL) (CH) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11472771-B2 | Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts | ADH1C, ADH1A, DDC | HAO1 3372/4885MAPK14 529/4885TNK2 3160/4885 |
| US-20210382038-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | NOTCH3, NOTCH1, NOTCH4 | HAO1 4092/4885MAPK14 774/4885TNK2 1314/4885 |
| US-20190219566-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | NOTCH3, NOTCH1, NOTCH4 | HAO1 4092/4885MAPK14 774/4885TNK2 1314/4885 |
| US-20220185793-A1 | COMPOUNDS FOR THE TREATMENT OF ONCOVIRUS INDUCED CANCER AND METHODS OF USE THEREOF | TP53, HAVCR2, AQP1 | HAO1 3204/4885MAPK14 1287/4885TNK2 2792/4885 |
| US-20140329867-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | NOTCH3, NOTCH1, NOTCH4 | HAO1 3641/4885MAPK14 334/4885TNK2 1658/4885 |
| US-20220388961-A1 | PROCESS FOR MAKING AMINO DIARYL ETHERS AND AMINO DIARYL ETHERS HYDROCHLORIDE SALTS | ADH1C, ADH1A, DDC | HAO1 3372/4885MAPK14 529/4885TNK2 3160/4885 |
| US-12030855-B2 | Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts | ADH1C, ADH1A, DDC | HAO1 3372/4885MAPK14 529/4885TNK2 3160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.