SCHEMBL15080489

SCHEMBL15080489

O=C(CI)Nc1cccc(C(=O)ON2C(=O)CC([SH](=O)=O)C2=O)c1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.43
KMT2A Q03164 3/20 0.41
LMNA P02545 4/20 0.40
ALDH1A1 P00352 7/20 0.39
TSHR P16473 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MEN1 O00255 1/20 0.37
HSD17B10 Q99714 1/20 0.37
HPGD P15428 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HIF1A Q16665 1/20 0.36
EPAS1 Q99814 1/20 0.36
ABL1 P00519 1/20 0.36
RIN1 Q13671 1/20 0.36
MAPK1 P28482 1/20 0.35
NPC1 O15118 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10105974 0.83 L3MBTL1 (0.42) L3MBTL1KMT2ALMNAALDH1A1TSHR
SCHEMBL10076741 0.81 L3MBTL1 (0.45) L3MBTL1KMT2ALMNAALDH1A1TSHR
SCHEMBL15080488 0.74 MAPK1 (0.43) L3MBTL1KMT2AALDH1A1SMN1; SMN2MEN1
SCHEMBL13221517 0.72 ALDH1A1 (0.42) KMT2ALMNAALDH1A1MEN1HPGD
SCHEMBL2633144 0.72 ALDH1A1 (0.44) KMT2ALMNAALDH1A1SMN1; SMN2MEN1
SCHEMBL12092089 0.70 L3MBTL1 (0.54) L3MBTL1KMT2ALMNAALDH1A1TSHR
SCHEMBL2179698 0.69 ALDH1A1 (0.40) KMT2ALMNAALDH1A1SMN1; SMN2MEN1
SCHEMBL15786837 0.69 RAB9A (0.41) L3MBTL1KMT2AALDH1A1SMN1; SMN2MEN1
SCHEMBL3869823 0.69 HDAC3 (0.44) L3MBTL1KMT2ALMNAALDH1A1SMN1; SMN2
SCHEMBL29382448 0.68 ALDH1A1 (0.38) L3MBTL1KMT2ALMNAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11701433-B2 Complexes for delivery of antigenic peptides THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2023-07-18 US disclosed
US-8475765-B2 Hydroxyalkyl starch derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2013-07-02 US disclosed
US-20110054152-A1 Hydroxyalkyl Starch Derivatives FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2011-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11701433-B2 Complexes for delivery of antigenic peptides IFNG, ALB, IFNAR1 L3MBTL1 3246/4885KMT2A 3440/4885LMNA 2853/4885
US-20110054152-A1 Hydroxyalkyl Starch Derivatives GRHPR, DCXR, HRH2 L3MBTL1 4571/4885KMT2A 4511/4885LMNA 2774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.