Sugi Predict

Sugi Predict / Compounds / SCHEMBL1522407

SCHEMBL1522407

SCHEMBL1522407

O=c1[nH]c2sccc2c(=O)o1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TNKS2 Q9H2K2 6/20 0.47
▸ PARP15 Q460N3 5/20 0.47
▸ ALDH1A1 P00352 3/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ TNKS O95271 1/20 0.47
▸ PARP1 P09874 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ F2 P00734 2/20 0.46
▸ CFD P00746 1/20 0.46
▸ ERCC1 P07992 1/20 0.44
▸ ERCC5 P28715 1/20 0.44
▸ FEN1 P39748 1/20 0.44
▸ ERCC4 Q92889 1/20 0.44
▸ PARP10 Q53GL7 4/20 0.41
▸ PARP2 Q9UGN5 4/20 0.41
▸ DAO P14920 1/20 0.39
▸ PARP14 Q460N5 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.36
▸ ELANE P08246 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1285397 0.68 PDPK1 (0.46) ALDH1A1F2CFDDAOELANE
SCHEMBL5278947 0.68 PARP15 (0.43) TNKS2PARP15ALDH1A1MEN1KMT2A
SCHEMBL15260259 0.67 ELANE (0.40) TNKS2PARP15ALDH1A1MEN1KMT2A
SCHEMBL993597 0.67 KMT2A (0.66) TNKS2PARP15ALDH1A1MEN1KMT2A
SCHEMBL3932932 0.65 F2 (0.39) ALDH1A1F2CFDKDM4EELANE
SCHEMBL1523309 0.65 F2 (0.52) F2CFDCLK4MAPK8CDK5
SCHEMBL29478203 0.64 TNKS2 (1.00) TNKS2PARP15ALDH1A1MEN1KMT2A
SCHEMBL422013 0.64 TNKS2 (1.00) TNKS2PARP15ALDH1A1MEN1KMT2A
SCHEMBL3233768 0.64 ALDH1A1 (1.00) TNKS2PARP15ALDH1A1MEN1KMT2A
SCHEMBL30590336 0.63 TNKS2 (0.48) TNKS2PARP15ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090758-A1 AHR AGONISTS ELI LILLY AND COMPANY (US) 2025-05-01 — — WO disclosed
CN-113646046-B Salts of pentacyclic compounds and crystals thereof 卫材R&D管理有限公司 2024-05-17 — — CN disclosed
US-11420980-B2 Salt of pentacyclic compound and crystal thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2022-08-23 — — US disclosed
CN-111051316-B Pentacyclic compounds 卫材R&D管理有限公司 2022-05-31 — — CN disclosed
EP-3936189-A1 SALT OF PENTACYCLIC COMPOUND AND CRYSTALS THEREOF Eisai R&D Management Co., Ltd. (JP) 2022-01-12 — — EP disclosed
EP-3936189-A1 SALT OF PENTACYCLIC COMPOUND AND CRYSTALS THEREOF Eisai R&D Management Co., Ltd. (JP) 2022-01-12 — — EP disclosed
CN-113646046-A Salt of pentacyclic compound and crystal thereof 卫材R&D管理有限公司 2021-11-12 — — CN disclosed
EP-3680243-B1 PENTACYCLIC COMPOUND EISAI R&D MAN CO LTD (JP) 2021-10-27 — — EP disclosed
EP-3680243-B1 PENTACYCLIC COMPOUND EISAI R&D MAN CO LTD (JP) 2021-10-27 — — EP disclosed
WO-2021105335-A1 PIPERIDINE-2, 6-DIONE DERIVATIVES WHICH BIND TO CEREBLON, AND METHODS OF USE THEREOF CAPTOR THERAPEUTICS S.A. (PL) 2021-06-03 — — WO disclosed
EP-1786807-A1 HETEROCYCLIC ANTIVIRAL COMPOUNDS F.HOFFMANN-LA ROCHE AG (CH) 2007-05-23 — — EP disclosed
US-20060229314-A1 Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors AVANIR PHARMACEUTICALS 2006-10-12 — — US disclosed
US-20060167247-A1 Urea inhibitors of MAP kinases LOCUS PHARMACEUTICALS, INC. 2006-07-27 — — US disclosed
WO-2006021340-A1 HETEROCYCLIC ANTIVIRAL COMPOUNDS F.HOFFMANN-LA ROCHE AG (CH) 2006-03-02 — — WO disclosed
US-20060040927-A1 Heterocyclic antiviral compounds ROCHE PALO ALTO LLC 2006-02-23 — — US disclosed
US-20050075331-A1 Anti-infective agents ABBOTT LABORATORIES 2005-04-07 — — US disclosed
US-20050014793-A1 Pyridinone derivatives for treatment of atherosclerosis GLAXO GROUP LIMITED (GB) 2005-01-20 — — US disclosed
US-20040167123-A1 Anti-infective agents ABBVIE INC. 2004-08-26 — — US disclosed
US-20040097492-A1 Anti-infective agents ABBOTT LABORATORIES 2004-05-20 — — US disclosed
US-20040087577-A1 Anti-infective agents ABBOTT LABORATORIES 2004-05-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040097492-A1 Anti-infective agents POLR1C, RPL5, POLB TNKS2 3808/4885PARP15 3433/4885ALDH1A1 1434/4885
US-20050014793-A1 Pyridinone derivatives for treatment of atherosclerosis PNPO, PLA2G7, PLA2G4B TNKS2 1341/4885PARP15 975/4885ALDH1A1 529/4885
US-11420980-B2 Salt of pentacyclic compound and crystal thereof REN, SLC10A1, SLC10A6 TNKS2 4410/4885PARP15 3522/4885ALDH1A1 2089/4885
US-20060229314-A1 Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors MIF, MMP12, MSR1 TNKS2 2040/4885PARP15 3706/4885ALDH1A1 3434/4885
US-20040167123-A1 Anti-infective agents SERPINB1, CYP51A1, ZC3HAV1 TNKS2 3643/4885PARP15 2304/4885ALDH1A1 891/4885
US-20050075331-A1 Anti-infective agents RPL35, POLI, POLRMT TNKS2 3260/4885PARP15 1904/4885ALDH1A1 1592/4885
US-20060040927-A1 Heterocyclic antiviral compounds HAVCR2, POLR1A, HCCS TNKS2 2832/4885PARP15 2017/4885ALDH1A1 113/4885
US-20040087577-A1 Anti-infective agents POLR1C, RPL5, POLB TNKS2 3808/4885PARP15 3433/4885ALDH1A1 1434/4885
US-20060167247-A1 Urea inhibitors of MAP kinases MAPK1, MAP3K1, MAP3K20 TNKS2 1648/4885PARP15 2287/4885ALDH1A1 2027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.