Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.69 |
| ▸ | CA9 | Q16790 | 6/20 | 0.69 |
| ▸ | CA2 | P00918 | 4/20 | 0.69 |
| ▸ | CA1 | P00915 | 4/20 | 0.69 |
| ▸ | CA4 | P22748 | 4/20 | 0.69 |
| ▸ | CA7 | P43166 | 2/20 | 0.69 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16491168 | 0.81 | CA12 (0.69) | CA12CA9CA2CA1CA4 | |
| SCHEMBL16491167 | 0.81 | CA2 (1.00) | CA12CA9CA2CA1CA4 | |
| SCHEMBL24604554 | 0.81 | CA12 (0.59) | CA12CA9CA2CA1CA4 | |
| SCHEMBL719717 | 0.81 | CA12 (0.69) | CA12CA9CA2CA1CA4 | |
| SCHEMBL5704167 | 0.79 | CA12 (0.63) | CA12CA9CA2CA1CA4 | |
| SCHEMBL3848565 | 0.79 | ADAM17 (0.63) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL17676471 | 0.79 | CA12 (0.65) | CA12CA9CA2CA1CA4 | |
| SCHEMBL6275169 | 0.77 | CA12 (0.44) | CA12CA9CA2CA1CA4 | |
| Hydrochloric Acid SCHEMBL21694040 | 0.77 | CA12 (0.61) | CA12CA9CA2CA1CA4 | |
| SCHEMBL16473958 | 0.75 | CA12 (0.59) | CA12CA9CA2CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12366579-B2 | Sulfur-heterocycle exchange chemistry and uses thereof | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2025-07-22 | — | — | US | disclosed |
| US-12018097-B2 | Non-chromatographic purification of macrocyclic peptides by a resin catch and release | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-06-25 | — | — | US | disclosed |
| US-12018097-B2 | Non-chromatographic purification of macrocyclic peptides by a resin catch and release | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-06-25 | — | — | US | disclosed |
| US-11479581-B2 | Non-chromatographic purification of macrocyclic peptides by a resin catch and release | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-10-25 | — | — | US | disclosed |
| US-20220305121-A1 | N-ARYL SULFONAMIDE DERIVATIVES AS VACCINE ADJUVANT | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-09-29 | — | — | US | disclosed |
| US-20220214355-A1 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-07-07 | — | — | US | disclosed |
| US-20220214355-A1 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-07-07 | — | — | US | disclosed |
| CN-113853372-A | Thio-heterocyclic exchange chemistry and uses thereof | 弗吉尼亚大学专利基金委员会 | 2021-12-28 | — | — | CN | disclosed |
| EP-3924348-A2 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | University of Virginia Patent Foundation (US) | 2021-12-22 | — | — | EP | disclosed |
| US-20210079046-A1 | NON-CHROMATOGRAPHIC PURIFICATION OF MACROCYCLIC PEPTIDES BY A RESIN CATCH AND RELEASE | BRISTOL-MYERS SQUIBB COMPANY | 2021-03-18 | — | — | US | disclosed |
| US-20160263234-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. | 2016-09-15 | — | — | US | disclosed |
| US-9315542-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2016-04-19 | — | — | US | disclosed |
| US-9309283-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| EP-2869820-A2 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | Onyx Therapeutics, Inc. (US) | 2015-05-13 | — | — | EP | disclosed |
| US-20150051242-A1 | RAFAMYCIN ANALOGS AND METHODS FOR MAKING SAME | ZHEJIANG ZYLOX MEDICAL DEVICE CO., LTD. (CN) | 2015-02-19 | — | — | US | disclosed |
| US-20150051242-A1 | RAFAMYCIN ANALOGS AND METHODS FOR MAKING SAME | ZHEJIANG ZYLOX MEDICAL DEVICE CO., LTD. (CN) | 2015-02-19 | — | — | US | disclosed |
| US-20140105921-A1 | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors | ONYX THERAPEUTICS, INC. | 2014-04-17 | — | — | US | disclosed |
| US-20140100168-A1 | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors | ONYX THERAPEUTICS, INC. | 2014-04-10 | — | — | US | disclosed |
| US-20140100154-A1 | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors | ONYX THERAPEUTICS, INC. (US) | 2014-04-10 | — | — | US | disclosed |
| WO-2014011695-A2 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. (US) | 2014-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140105921-A1 | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors | PREP, VIP, PEPD | CA12 1194/4885CA9 824/4885CA2 2908/4885 |
| US-20210079046-A1 | NON-CHROMATOGRAPHIC PURIFICATION OF MACROCYCLIC PEPTIDES BY A RESIN CATCH AND RELEASE | ANPEP, DNPEP, NPR1 | CA12 2754/4885CA9 2499/4885CA2 3509/4885 |
| US-20220214355-A1 | SULFUR-HETEROCYCLE EXCHANGE CHEMISTRY AND USES THEREOF | TST, TPST2, SRMS | CA12 3992/4885CA9 4162/4885CA2 3500/4885 |
| US-11479581-B2 | Non-chromatographic purification of macrocyclic peptides by a resin catch and release | ANPEP, NPR1, DNPEP | CA12 2922/4885CA9 2619/4885CA2 3615/4885 |
| US-20140100168-A1 | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors | PREP, VIP, PEPD | CA12 1194/4885CA9 824/4885CA2 2908/4885 |
| US-20160263234-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | PREP, VIP, PEPD | CA12 1194/4885CA9 824/4885CA2 2908/4885 |
| US-20140100154-A1 | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors | PREP, VIP, PEPD | CA12 1194/4885CA9 824/4885CA2 2908/4885 |
| US-12018097-B2 | Non-chromatographic purification of macrocyclic peptides by a resin catch and release | VIP, NPR1, NPPA | CA12 2593/4885CA9 2333/4885CA2 3731/4885 |
| US-20150051242-A1 | RAFAMYCIN ANALOGS AND METHODS FOR MAKING SAME | RICTOR, MTOR, RPTOR | CA12 3665/4885CA9 1816/4885CA2 3528/4885 |
| US-12366579-B2 | Sulfur-heterocycle exchange chemistry and uses thereof | TST, TPST2, SRMS | CA12 3992/4885CA9 4162/4885CA2 3500/4885 |
| US-20220305121-A1 | N-ARYL SULFONAMIDE DERIVATIVES AS VACCINE ADJUVANT | TLR1, TLR3, TLR2 | CA12 4726/4885CA9 4809/4885CA2 3606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.