SCHEMBL15471663

SCHEMBL15471663

CCc1ccc(-c2ccc(CC)c(F)c2F)cc1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 2/20 0.40
FEN1 P39748 2/20 0.40
ESR1 P03372 2/20 0.36
ESR2 Q92731 2/20 0.36
BDKRB1 P46663 7/20 0.35
CHKA P35790 1/20 0.35
PDE3B Q13370 1/20 0.34
PDE3A Q14432 1/20 0.34
LTB4R2 Q9NPC1 1/20 0.34
SCN9A Q15858 1/20 0.33
CTSL P07711 1/20 0.33
CTSS P25774 1/20 0.33
CTSK P43235 1/20 0.33
PTPRC P08575 1/20 0.33
PTPN1 P18031 1/20 0.33
KDM4E B2RXH2 1/20 0.32
NPC1 O15118 1/20 0.32
LMNA P02545 1/20 0.32
POLB P06746 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17359270 0.91 ALOX5AP (0.37) ALOX5APFEN1ESR1ESR2BDKRB1
SCHEMBL17356562 0.91 AKR1C3 (0.40) ALOX5APFEN1ESR1ESR2CHKA
SCHEMBL17356572 0.88 AKR1C3 (0.44) ALOX5APFEN1ESR1ESR2PDE3B
SCHEMBL19229308 0.84 ALOX5AP (0.43) ALOX5APFEN1PDE3BPDE3APTPRC
SCHEMBL18779778 0.84 PDE3B (0.41) ALOX5APFEN1CHKAPDE3BPDE3A
SCHEMBL10303318 0.84 CTSL (0.42) ALOX5APFEN1ESR1ESR2CHKA
SCHEMBL10303305 0.84 CTSL (0.39) ALOX5APFEN1ESR1ESR2CHKA
SCHEMBL16377216 0.84 RARB (0.42) ALOX5APFEN1CHKALTB4R2NPC1
SCHEMBL16852389 0.84 PTGS2 (0.49) KDM4ENPC1LMNAPOLBHPGD
SCHEMBL19755018 0.84 SCN9A (0.35) ALOX5APFEN1CHKASCN9ACTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10041000-B2 Liquid crystal display device JNC CORPORATION (JP) 2018-08-07 US disclosed
US-20180208849-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-07-26 US disclosed
US-10030198-B2 Liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2018-07-24 US disclosed
US-20180201836-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-07-19 US disclosed
US-20180163132-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-06-14 US disclosed
US-20180163138-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-06-14 US disclosed
US-9994768-B2 Liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2018-06-12 US disclosed
US-9969935-B2 Liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2018-05-15 US disclosed
US-20180127651-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-05-10 US disclosed
US-20180127650-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-05-10 US disclosed
US-20150329780-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2015-11-19 US disclosed
US-20150299575-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2015-10-22 US disclosed
US-20150284637-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2015-10-08 US disclosed
US-20150240160-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2015-08-27 US disclosed
US-20150240161-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2015-08-27 US disclosed
US-20150129801-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2015-05-14 US disclosed
US-20150108402-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2015-04-23 US disclosed
US-8968597-B2 Liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-03-03 US disclosed
US-20140284523-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-09-25 US disclosed
US-20140043579-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2014-02-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180127651-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE LASP1, PYCARD, CRYAA ALOX5AP 1104/4885FEN1 2689/4885ESR1 4541/4885
US-20150240160-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE CFD, DRD2, DRD1 ALOX5AP 982/4885FEN1 4391/4885ESR1 4525/4885
US-20150129801-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE BACE1, DRD1, CHRM1 ALOX5AP 273/4885FEN1 755/4885ESR1 4535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.