SCHEMBL1551786

SCHEMBL1551786

Fc1ccc2cnccc2c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.53
CYP1A2 P05177 1/20 0.50
CYP2A6 P11509 1/20 0.50
CYP19A1 P11511 2/20 0.46
ACHE P22303 1/20 0.44
PIK3CA P42336 1/20 0.44
ROCK2 O75116 2/20 0.43
CHUK O15111 1/20 0.43
PRKCZ Q05513 1/20 0.41
IMPDH2 P12268 2/20 0.41
CYP11B2 P19099 1/20 0.41
BACE1 P56817 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
ROCK1 Q13464 1/20 0.40
MKNK2 Q9HBH9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30387605 1.00 MAPT (0.53) MAPTCYP1A2CYP2A6CYP19A1ACHE
Hydrochloric Acid SCHEMBL2341695 0.98 MAPT (0.51) MAPTCYP1A2CYP2A6CYP19A1ACHE
SCHEMBL29875363 0.91 PRKCZ (0.50) MAPTCYP1A2CYP2A6CYP19A1ACHE
SCHEMBL11144191 0.91 PRKCZ (0.50) MAPTCYP1A2CYP2A6CYP19A1ACHE
SCHEMBL23557738 0.81 CHUK (0.47) MAPTCYP1A2CYP2A6CYP19A1ACHE
SCHEMBL22490163 0.79 HIPK2 (0.53) MAPTCYP1A2CYP2A6ACHECHUK
SCHEMBL25625877 0.79 CHUK (0.46) MAPTCYP1A2CYP2A6CYP19A1ACHE
SCHEMBL21415736 0.79 CYP11B2 (0.53) CYP19A1PIK3CAROCK2PRKCZCYP11B2
SCHEMBL18201498 0.79 ROCK2 (0.52) MAPTCYP1A2ROCK2IMPDH2ROCK1
SCHEMBL6562601 0.77 CYP1A2 (0.77) CYP1A2CYP2A6BACE1L3MBTL1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 219 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805204-B Method for preparing 4-iodoisoquinoline-1 (2H) -ketone compound 云南师范大学 2023-09-15 CN claimed
CN-115055128-A Preparation method of cyclopropyl-substituted nitrogen-containing six-membered heterocyclic compound 北京六合宁远医药科技股份有限公司 2022-09-16 CN claimed
US-10077261-B2 Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer JANSSEN PHARMACEUTICA NV (BE) 2018-09-18 US claimed
EP-2892892-B1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER JANSSEN PHARMACEUTICA NV (BE) 2017-05-31 EP claimed
US-20160002219-A1 IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER JANSSEN PHARMACEUTICA NV (BE) 2016-01-07 US claimed
EP-2892892-A1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR!THE TREATMENT OF CANCER Janssen Pharmaceutica N.V. (BE) 2015-07-15 EP claimed
US-20150099730-A1 IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER JANSSEN PHARMACEUTICA, NV (BE) 2015-04-09 US claimed
WO-2014039769-A1 IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FATTY ACID SNTHASE (FASN) INHIBITORS FOR|THE TREATMENT OF CANCER JANSSEN PHARMACEUTICA NV (BE) 2014-03-13 WO claimed
CN-122055343-A Deuterium and aryl amine compounds and uses thereof 泽农医药公司 2026-05-15 CN disclosed
US-12528774-B2 Thiosemicarbazone compounds and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-01-20 US disclosed
US-12528828-B2 Substituted pyrido[4,3-d]pyrimidines as KRAS modulators ALTEROME THERAPEUTICS, INC. (US) 2026-01-20 US disclosed
US-20250346610-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS ALTEROME THERAPEUTICS INC (US) 2025-11-13 US disclosed
US-12466842-B2 Substituted pyrido [4,3-d]pyrimidines as KRAS modulators ALTEROME THERAPEUTICS, INC. (US) 2025-11-11 US disclosed
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof BAUSCH + LOMB IRELAND LIMITED (IE) 2025-10-07 US disclosed
WO-2005046712-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2005-05-26 WO disclosed
US-20050090432-A1 Macrocyclic isoquinoline peptide inhibitors of Hepatitis C virus BRISTOL-MYERS SQUIBB COMPANY 2005-04-28 US disclosed
EP-1505963-A1 HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2005-02-16 EP disclosed
WO-2004094452-A2 MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-11-04 WO disclosed
US-20040106559-A1 Hepatitis C virus inhibitors BRISTOL-MYERS SQUIBB COMPANY 2004-06-03 US disclosed
WO-2003099274-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2003-12-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof TRPV1, TRPV3, TRPV2 MAPT 1757/4885CYP1A2 1653/4885CYP2A6 1400/4885
US-20250346610-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS KRAS, NRAS, HRAS MAPT 3604/4885CYP1A2 4415/4885CYP2A6 3387/4885
US-12466842-B2 Substituted pyrido [4,3-d]pyrimidines as KRAS modulators KRAS, NRAS, HRAS MAPT 3604/4885CYP1A2 4415/4885CYP2A6 3387/4885
US-20150099730-A1 IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER FASN, PLIN1, FABP1 MAPT 4730/4885CYP1A2 439/4885CYP2A6 1519/4885
US-10077261-B2 Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer FASN, PLIN1, FABP1 MAPT 4730/4885CYP1A2 439/4885CYP2A6 1519/4885
US-20050090432-A1 Macrocyclic isoquinoline peptide inhibitors of Hepatitis C virus VIP, QPCT, HCCS MAPT 4318/4885CYP1A2 2722/4885CYP2A6 2940/4885
US-12528828-B2 Substituted pyrido[4,3-d]pyrimidines as KRAS modulators KRAS, NRAS, HRAS MAPT 3501/4885CYP1A2 2753/4885CYP2A6 1929/4885
US-12528774-B2 Thiosemicarbazone compounds and uses thereof SCN2B, SCN1B, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 MAPT 3717/4885CYP1A2 648/4885CYP2A6 898/4885
US-20160002219-A1 IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER FASN, PLIN1, FABP1 MAPT 4730/4885CYP1A2 439/4885CYP2A6 1519/4885
US-20040106559-A1 Hepatitis C virus inhibitors HAVCR2, HCCS, RNASE1 MAPT 4314/4885CYP1A2 138/4885CYP2A6 325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.