Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25056422 | 0.84 | LMNA (0.49) | JMJD6MEN1KMT2ANPC1MAPK1 | |
| SCHEMBL11108995 | 0.83 | KDM4E (0.42) | SMN1; SMN2JMJD6MEN1KMT2ANPC1 | |
| SCHEMBL14394389 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2ARECQLPKM | |
| SCHEMBL16156123 | 0.77 | EPHX2 (0.42) | SMN1; SMN2JMJD6KMT2ANPC1RAB9A | |
| SCHEMBL12956415 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2JMJD6KMT2ANPC1RAB9A | |
| SCHEMBL2983517 | 0.75 | GLS (0.41) | SMN1; SMN2JMJD6NPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL23581663 | 0.75 | EPHX2 (0.41) | SMN1; SMN2JMJD6KMT2ANPC1RAB9A | |
| SCHEMBL29014035 | 0.75 | ALDH1A1 (0.56) | SMN1; SMN2MEN1KMT2AMAPK1RECQL | |
| SCHEMBL3377744 | 0.74 | TSHR (0.50) | SMN1; SMN2JMJD6MEN1KMT2ANPC1 | |
| SCHEMBL22170063 | 0.74 | CYP1A2 (0.40) | SMN1; SMN2JMJD6NPC1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117903140-A | Imidazopyrimidines and triazolopyrimidines as A2A/A2B inhibitors | 因赛特公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-108863850-B | Biaryl compound and preparation method and application thereof | 复旦大学 | 2021-05-18 | — | — | CN | disclosed |
| CN-112384515-A | Imidazopyrimidines and triazolopyrimidines as A2A/A2B inhibitors | 因赛特公司 | 2021-02-19 | — | — | CN | disclosed |
| US-10844017-B2 | Biaryl compound, preparation method and use thereof | FUDAN UNIVERSITY (CN) | 2020-11-24 | — | — | US | disclosed |
| EP-2844652-B1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2019-03-13 | — | — | EP | disclosed |
| CN-108863850-A | Biaryl base class compound and its preparation method and application | 复旦大学 | 2018-11-23 | — | — | CN | disclosed |
| US-9212173-B2 | Pyrazole aminopyrimidine derivatives as LRRK2 modulators | GENENTECH, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| EP-2844652-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2015-03-11 | — | — | EP | disclosed |
| US-20150051238-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH, INC. (CA) | 2015-02-19 | — | — | US | disclosed |
| WO-2013164321-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844017-B2 | Biaryl compound, preparation method and use thereof | RORC, RORB, RORA | SMN1; SMN2 4691/4885JMJD6 1637/4885MEN1 4069/4885 |
| US-20150051238-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | LRRK2, PARK7, PINK1 | SMN1; SMN2 873/4885JMJD6 3616/4885MEN1 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.