Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15535647 | 0.82 | DRD2 (0.47) | DRD2TAS1R3TAS1R1HTR3EHTR3B | |
| SCHEMBL15534816 | 0.82 | P2RX7 (0.47) | DRD2TAS1R3TAS1R1HTR3EHTR3B | |
| SCHEMBL15535203 | 0.79 | GNRHR (0.48) | CNR2HTR4 | |
| SCHEMBL15535202 | 0.79 | GNRHR (0.48) | CNR2HTR4 | |
| SCHEMBL1666992 | 0.79 | ALDH1A1 (0.46) | DRD2SLC6A2SLC6A4HTR3EHTR3B | |
| SCHEMBL22447716 | 0.75 | DRD2 (0.44) | DRD2HTR3EHTR3BHTR3AHTR4 | |
| SCHEMBL1666286 | 0.68 | SLC6A2 (0.40) | CNR2SLC6A2SLC6A4HPGDKDM4E | |
| SCHEMBL1668136 | 0.68 | HPGD (0.50) | HPGDSMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL10169374 | 0.68 | EPHX1 (0.46) | DRD2SLC6A2ALDH1A1GAAHTT | |
| SCHEMBL10169373 | 0.68 | EPHX1 (0.46) | DRD2SLC6A2ALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177349-A2 | QUINAZOLINEDIONES AS TANKYRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |