Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 10/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15535647 | 0.87 | DRD2 (0.47) | TAS1R3TAS1R1DRD2HTR3EHTR3B | |
| SCHEMBL15534876 | 0.82 | DRD2 (0.38) | TAS1R3TAS1R1DRD2HTR3EHTR3B | |
| SCHEMBL1666992 | 0.81 | ALDH1A1 (0.46) | DRD2HTR3EHTR3BHTR3AHTR4 | |
| SCHEMBL1666286 | 0.71 | SLC6A2 (0.40) | DPP4 | |
| SCHEMBL22447716 | 0.71 | DRD2 (0.44) | DRD2HTR3EHTR3BHTR3AHTR4 | |
| SCHEMBL8932345 | 0.71 | P2RX7 (0.57) | P2RX7SLC6A9JAK1 | |
| SCHEMBL9017627 | 0.70 | MAPK14 (0.55) | P2RX7TAS1R3TAS1R1JAK1TAS1R2 | |
| SCHEMBL1668136 | 0.69 | HPGD (0.50) | — | |
| SCHEMBL8732695 | 0.69 | P2RX7 (0.58) | P2RX7SLC6A9JAK1 | |
| SCHEMBL15534872 | 0.68 | CCNA2 (0.45) | PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177349-A2 | QUINAZOLINEDIONES AS TANKYRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |